Space of Disse
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The space of Disse (or perisinusoidal space) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be taken up by the hepatocytes. This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).
The Space of Disse also contains Ito cells which store fat or fat soluble vitamins (like vitamin A). Excessive intake of fat soluble vitamins can lead to pathologically enlarged Ito cells, which can form collagen and lead to fibrosis and cirrhosis.
The Space of Disse was named after German anatomist, Joseph Disse (1852–1912).
External links
- UIUC Histology Subject 1317
- Histology at BU 22103loa - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
- Histology at BU 15204loa - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
- Organology at UC Davis digestive/mammal/liver5/liver7 - "Mammal, liver (EM, Low)"
Anatomy of torso, digestive system: Digestive glands | |
|---|---|
| Liver | by region: Left lobe (Caudate lobe, Quadrate lobe) • Right lobe • Transverse fissure of liver
by function: Fibrous capsule of Glisson • Hepatocyte • Space of Disse • Space of Mall • Kupffer cell • Liver sinusoid • Ito cell • Hepatic lobule bile ducts: Bile canaliculus • Canals of Hering • Interlobular bile ducts • Intrahepatic bile ducts • Left and Right hepatic ducts • Common hepatic duct |
| Gallbladder | by region: Body • Fundus • Neck ducts: Cystic duct |
| Pancreas | by region: Tail • Body • Head • Uncinate process
by function: Islets of Langerhans • Exocrine pancreas ducts: Pancreatic duct • Accessory pancreatic duct |
| Common | Common bile duct • Hepatopancreatic ampulla • Sphincter of Oddi |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
