Stratum spinosum

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Stratum spinosum
Section of epidermis.
Gray's	subject #234 1063

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In the skin, the stratum spinosum is a multi-layered arrangement of cuboidal cells that sits beneath the stratum granulosum. Adjacent cells are joined by desmosomes, giving them a spiny appearance when the cells shrink during the staining process while the desmosomes hold firm. Their nuclei are often darkened (a condition called pyknosis), which is an early sign of cell death. Their fate is sealed because the nutrients and oxygen in interstitial fluid have become exhausted before the fluid is able to reach them by diffusion.

Cells of the stratum spinosum actively synthesize intermediate filaments called cytokeratins, which are composed of keratin. These intermediate filaments are anchored to the desmosomes, joining adjacent cells to provide structural support, helping the skin resist abrasion.

Additional images

Cross-section of all skin layers.

External links

• Histology at BU 08422loa - "Integument: thick skin"

v • d • e Integumentary system
Skin layers	cutis: Epidermis (Stratum corneum, Stratum lucidum, Stratum granulosum, Stratum spinosum, Stratum germinativum/basale) • Dermis Subcutaneous tissue
Skin appendages	glands: Sweat glands (Eccrine, Apocrine) • Sebaceous glands hair: Root of the hair • Hair follicle • Root sheath (Huxley's layer, Henle's layer) nails: Eponychium • Lunula nonhuman: Scale • Feather

fr:Stratum spinosum

lt:Dygliuotasis sluoksnis

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .