Submucosa

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Submucosa
LAYERS: serosa longitudinal muscle myenteric plexus circular muscle submucosal plexus submucosal mucosal
Endoscopy and radial endoscopic ultrasound images of submucosal tumour in mid-esophagus. The submucosa is seen as a dark ring on the ultrasound image.
Dorlands/Elsevier	s_27/12765896

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In the gastrointestinal tract, the submucosa is the layer of loose connective tissue that supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle (fibers running circularly within layer of longitudinal muscle).

Contents

Blood vessels, lymphatic vessels, and nerves (all supplying the mucosa) will run through here.

Tiny parasympathetic ganglia are scattered around forming the submucosal plexus (or "Meissner's plexus") where preganglionic parasympathetic neurons synapse with postganglionic nerve fibers that supply the muscularis mucosae.

The submucosa in endoscopy

Identification of the submucosa plays an important role in diagnostic and therapeutic endoscopy, where special fibre-optic cameras are used to perform procedures on the gastrointestinal tract. Abnormalities of the submucosa, such as gastrointestinal stromal tumors, usually show integrity of the mucosal surface.

The submucosa is also identified in endoscopic ultrasound to identify the depth of tumours and to identify other abnormalities. An injection of dye, saline, or epinephrine into the submucosa is imperative in the safe removal of certain polyps.

Endoscopic mucosal resection involves removal of the mucosal layer, and in order to be done safely, a submucosal injection of dye is performed to ensure integrity at the beginning of the procedure.

See also

• Small intestinal submucosa

Additional images

Bladder.	Stomach.	Section of the human esophagus. Moderately magnified.	Vertical section of bladder wall.
General structure of the gut wall showing the submucosa.

External links

• Organology at UC Davis Digestive/mammal/system1/system5 - "Mammal, whole system (LM, Low)"
• submucosa at eMedicine Dictionary
• Histology at BU 00102loa - "Tissues, Layers, and Organs: transverse section of rat gut"
• Physiology at MCG 6/6ch1/s6ch1_9
• Histology at OU 55_11
• Anatomy Atlases - Microscopic Anatomy, plate 10.193 - "Duodenum and Jejunum"
• Histology at edteched.uottawa.ca

v • d • e tissue layers
mesothelium, serosa/adventitia, muscularis externa (outer & inner), submucosa, mucosa (muscularis mucosa, lamina propria, epithelium), lumen

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .