Syncoilin
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| syncoilin
| |
| Identifiers | |
| Symbol | SYNC1 |
| Entrez | 81493 |
| HUGO | 28897 |
| UniProt | Q9H7C4 |
| Other data | |
| Locus | Chr. 1 p34.3-p33 |
Syncoilin is a muscle-specific intermediate filament, first isolated by Newey and colleagues[1] as a binding partner to α-dystrobrevin, as determined by a yeast two-hybrid assay. Later, Poon and colleagues[1] used yeast two-hybrid methods to demonstrate that syncoilin is a binding partner of desmin. These binding partners suggest that syncoilin acts as a mechanical "linker" between the sarcomere Z-disk (where desmin is localized) and the dystrophin-associated protein complex (where α-dystrobrevin is localized). However, the specific in vivo functions of syncoilin have not yet been determined.
Abnormally high levels of syncoilin have been shown to be a characteristic of neuromuscular wasting diseases, such as desminopathy[1] and muscular dystrophy[1]. Therefore, syncoilin is being explored as a promising marker of neuromuscular disease.
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Proteins of the cytoskeleton | |
|---|---|
| Microfilaments | Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein |
| Intermediate filaments | type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) |
| Microtubules | Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin |
| Catenins | Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin |
| Nonhuman | Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) |
| Other | APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin |
