Syndecan 1
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| Syndecan 1
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| Identifiers | |||||||||||
| Symbol(s) | SDC1; CD138; SDC; SYND1; syndecan | ||||||||||
| External IDs | OMIM: 186355 MGI: 1349162 Homologene: 2252 | ||||||||||
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| RNA expression pattern | |||||||||||
| Image:PBB GE SDC1 201286 at tn.png | |||||||||||
| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 6382 | 20969 | |||||||||
| Ensembl | ENSG00000115884 | ENSMUSG00000020592 | |||||||||
| Uniprot | P18827 | Q3THY2 | |||||||||
| Refseq | NM_001006946 (mRNA) NP_001006947 (protein) | NM_011519 (mRNA) NP_035649 (protein) | |||||||||
| Location | Chr 2: 20.26 - 20.29 Mb | Chr 12: 8.8 - 8.82 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Syndecan 1 is a proteoglycan.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.[1]
References
Further reading
- David G (1992). "Structural and functional diversity of the heparan sulfate proteoglycans.". Adv. Exp. Med. Biol. 313: 69-78. PMID 1442271.
- Jaakkola P, Jalkanen M (1999). "Transcriptional regulation of Syndecan-1 expression by growth factors.". Prog. Nucleic Acid Res. Mol. Biol. 63: 109-38. PMID 10506830.
- Wijdenes J, Dore JM, Clement C, Vermot-Desroches C (2003). "CD138.". J. Biol. Regul. Homeost. Agents 16 (2): 152-5. PMID 12144130.
- Lories V, Cassiman JJ, Van den Berghe H, David G (1992). "Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts.". J. Biol. Chem. 267 (2): 1116-22. PMID 1339431.
- Vainio S, Jalkanen M, Bernfield M, Saxén L (1992). "Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney.". Dev. Biol. 152 (2): 221-32. PMID 1644217.
- Kiefer MC, Ishihara M, Swiedler SJ, et al. (1992). "The molecular biology of heparan sulfate fibroblast growth factor receptors.". Ann. N. Y. Acad. Sci. 638: 167-76. PMID 1664683.
- Ala-Kapee M, Nevanlinna H, Mali M, et al. (1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2.". Somat. Cell Mol. Genet. 16 (5): 501-5. PMID 2173154.
- Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (1990). "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans.". J. Biol. Chem. 265 (12): 6884-9. PMID 2324102.
- Sanderson RD, Lalor P, Bernfield M (1992). "B lymphocytes express and lose syndecan at specific stages of differentiation.". Cell Regul. 1 (1): 27-35. PMID 2519615.
- Asundi VK, Carey DJ (1995). "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region.". J. Biol. Chem. 270 (44): 26404-10. PMID 7592855.
- Zhang L, David G, Esko JD (1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans.". J. Biol. Chem. 270 (45): 27127-35. PMID 7592967.
- Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941-5. PMID 7690138.
- Spring J, Goldberger OA, Jenkins NA, et al. (1994). "Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family.". Genomics 21 (3): 597-601. doi:10.1006/geno.1994.1319. PMID 7959737.
- Sneed TB, Stanley DJ, Young LA, Sanderson RD (1994). "Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells.". Cell. Immunol. 153 (2): 456-67. doi:10.1006/cimm.1994.1042. PMID 8118875.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Kokenyesi R, Bernfield M (1994). "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.". J. Biol. Chem. 269 (16): 12304-9. PMID 8163535.
- Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor.". Oncogene 12 (2): 289-97. PMID 8570206.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
- Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A (1997). "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.". Hum. Genet. 99 (3): 295-7. PMID 9050911.
External links
Proteins: clusters of differentiation (see also list of human clusters of differentiation) | |
|---|---|
| 1-50 | CD1 (CD1a-c, CD1d) - CD2 - CD3 - CD4 - CD5 - CD8 - CD9 - CD10 - CD11 (CD11a, CD11b, CD11c) - CD13 - CD14 - CD15 - CD16 - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 - CD33 - CD34 - CD35 - CD36 - CD37 -CD38 - CD40 - CD43 - CD44 - CD45 - CD46 - CD49 (CD49a, CD49b, CD49c, CD49d) |
| 51-100 | CD52 - CD53 - CD54 - CD55 - CD56 - CD58 - CD59 - CD61 - CD62 (CD62E, CD62L, CD62P) - CD63 - CD64 - CD66e - CD68 - CD70 - CD71 - CD72 - CD79 - CD80 - CD81 - CD82 - CD83 - CD86 - CD88 - CD89 - CD90 - CD94 - CD95 - CD97 - CD98 |
| 101-350 | CD103 - CD106 - CD114 - CD116 - CD117 - CD118 - CD120 - CD122 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD137 - CD138 - CD141 - CD142 - CD143 - CD146 - CD147 - CD151 - CD152 - CD153 - CD154 - CD155 - CD162 - CD164 - CD169 - CD184 - CD206 - CD209 - CD257 - CD278 - CD281 - CD282 - CD283 - CD304 |
Glycoproteins: proteoglycans |
|---|
| Aggrecan - Biglycan - Decorin - Platelet factor 4 - Syndecan 1 - Versican |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
