Systemic inflammatory response syndrome

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In medicine, systemic inflammatory response syndrome (SIRS) is an inflammatory state of the whole body (the "system") without a proven source of infection. It is a serious medical condition.

Contents

Definition of SIRS

Criteria for SIRS were agreed in 1992.[1] SIRS can be diagnosed when two or more of the following are present[1][1][1][1]:

  • Heart rate > 90 beats per minute
  • Body temperature < 36 or > 38°C
  • Tachypnea (high respiratory rate) > 20 breaths per minute or, on blood gas, a PaCO2 < 4.3 kPa (32 mm Hg)
  • White blood cell count < 4000 cells/mm³ or > 12000 cells/mm³ (< 4 x 109 or > 12 x 109 cells/L), or the presence of greater than 10% immature neutrophils.

Difference between SIRS and sepsis

SIRS with a suspected or proven infection is called sepsis.

Simply stated:

SIRS + infection = sepsis [1][1]

Complications of SIRS

SIRS can result in the multiple organ dysfunction syndrome.

Causes of SIRS

Relation to cytokine storm

SIRS can be considered to be a subset of cytokine storm, a general term (not commonly used in clinical medicine) for cytokine dysregulation.

See also

References


Textbooks

External link

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