Tebanicline
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| Image:Tebanicline.png | |
| Tebanicline
| |
| Systematic (IUPAC) name | |
| 5-([(2R)-azetidin-2-yl]methoxy)-2-chloropyridine | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C9H11ClN2O |
| Mol. mass | 198.649 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Tebanicline (Ebanicline, ABT-594) is a drug which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.[1] It was developed as a less toxic analogue of the potent frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects.[1][1] Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound.[1][1][1][1][1][1]
Tebanicline got as far as Phase II trials in humans,[1] but was dropped from further development due to unacceptable incidence of gastrointestinal side effects.[1] However further research in this area is ongoing,[1][1][1][1] and it is expected that development of new neural nicotinic acetylcholine receptor agonists will be likely to lead to novel analgesics suitable for use in humans within the next few years.[1][1][1]
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References
Stimulants | |
|---|---|
| Alkylamines | Cyclopentamine • Geranamine • Isometheptene • Octodrine • Propylhexedrine • Tuamine |
| Alphapyrrolidinylalkiophenones | |
| Cholinergics | ABT-089 • ABT-418 • Anabasine • Arecoline • Cotinine • Cytisine • Dianicline • Epibatidine • Epiboxidine • GTS-21 • Ispronicline • Nicotine • Rivanicline • Tebanicline • Varenicline |
| Convulsants | Bicuculline • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone |
| Eugeroics | Adrafinil • Armodafinil • Carphedon • Modafinil |
| Phenethylamines | 4-Fluoroamphetamine • 4-Fluoromethamphetamine • 4-Methylmethcathinone • 4-MTA • Aletamine • Amphechloral • Amphetamine (Dextroamphetamine, Adderall) • Amphetaminil • Benzphetamine • Bupropion • Cathinone • Chlorphentermine • Clenbuterol • Clobenzorex • Clortermine • Diethylpropion • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Ephedrine • Epinephrine • Ethcathinone • Ethylamphetamine • Fenethylline • Fenfluramine • Fenproporex • Furfenorex • Levomethamphetamine • Lisdexamfetamine • MDMA • Mefenorex • Methamphetamine • Methcathinone • Methoxyphedrine • Methylone • Octopamine • Parahydroxyamphetamine • PMA • PMEA • PMMA • PPAP • Phendimetrazine • Phenmetrazine • Phentermine • Phenylephrine • Phenylpropanolamine • Propylamphetamine • Pseudoephedrine • Selegiline • Synephrine • Xylopropamine |
| Phenylaminooxazoles | |
| Piperazines | |
| Piperidines | |
| Tropanes | 3-Pseudotropyl-4-fluorobenzoate • Altropane • Brasofensine • CFT (WIN 35,428) • β-CIT (RTI-55) • Cocaethylene • Cocaine • β-CPPIT • Dichloropane (RTI-111) • FE-β-CPPIT • FP-β-CPPIT • PIT • PTT • RTI-32 • RTI-113 • RTI-121 (IPCIT) • RTI-336 • Tesofensine • Troparil (β-CPT, WIN 35,065-2) • WF-23 • WF-33 |
| Xanthines | Caffeine • Aminophylline • Paraxanthine • Theobromine • Theophylline |
| Others | Amineptine • Bemegride • Benzydamine • BPAP • BTQ • Clofenciclan • Cypenamine • Cyprodenate • Diclofensine • Dimethocaine • Diphenyl prolinol • Ethamivan • Fencamfamine • Feprosidnine • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • LR-5182 • Mazindol • Mesocarb • Naphthylisopropylamine • Nikethamide • Nomifensine • Phthalimidopropiophenone • Prolintane • Sibutramine • Yohimbine • Zylofuramine |
| See also Sympathomimetic amines | |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
