Tesofensine

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Image:Tesofensine.png
Tesofensine
Systematic (IUPAC) name
(2R,3S)-3-(3,4-dichlorophenyl)-2-ethoxymethyl- 8-methyl-8-azabicyclo[3.2.1]octane
Identifiers
CAS number	402856-42-2
ATC code	?
PubChem	?
Chemical data
Formula	C17H23Cl2NO
Mol. mass	328.28 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal
Routes	?

Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor, which also seems to increase the action of acetylcholine in the brain, probably due to downstream effects. It was originally researched for the treatment of Alzheimer's disease and Parkinson's Disease, but was subsequently dropped from development for these applications, and is now being researched for the treatment of obesity, presumably as an appetite suppressant. As of 2006 it was in Phase II trials for the treatment of obesity.[1]

References

Template:Pharmacology-stub

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Phenylaminooxazoles	4-Methyl-aminorex • Aminorex • Clominorex • Fenozolone • Fluminorex • Pemoline • Thozalinone
Piperazines	2C-B-BZP • BZP • GBR-12783 • GBR-12935 • GBR-13069 • GBR-13098 • GBR-13119 • MeOPP • MBZP • Vanoxerine
Piperidines	2-Benzylpiperidine • Desoxypipradrol • Ethylphenidate • (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane • Pipradrol
Tropanes	3-Pseudotropyl-4-fluorobenzoate • Altropane • Brasofensine • CFT (WIN 35,428) • β-CIT (RTI-55) • Cocaethylene • Cocaine • β-CPPIT • Dichloropane (RTI-111) • FE-β-CPPIT • FP-β-CPPIT • PIT • PTT • RTI-32 • RTI-113 • RTI-121 (IPCIT) • RTI-336 • Tesofensine • Troparil (β-CPT, WIN 35,065-2) • WF-23 • WF-33
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See also Sympathomimetic amines