Thyrotropin-releasing hormone receptor

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Thyrotropin-releasing hormone receptor
Identifiers
Symbol(s) TRHR; MGC141920
External IDs OMIM: 188545 MGI: 98824 Homologene: 20707
RNA expression pattern

Image:PBB GE TRHR 211438 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 7201 22045
Ensembl ENSG00000174417 ENSMUSG00000038760
Uniprot P34981 Q32MS1
Refseq NM_003301 (mRNA)
NP_003292 (protein) 		NM_013696 (mRNA)
NP_038724 (protein)
Location Chr 8: 110.17 - 110.2 Mb Chr 15: 44.03 - 44.06 Mb
Pubmed search [1] [2]

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[1][1] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.

References

Further reading

  • Short RE, James LF, Panter KE, et al. (1993). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.". J. Anim. Sci. 70 (11): 3498-504. PMID 1459912.
  • Yamada M, Iwasaki T, Satoh T, et al. (1996). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.". Neurosci. Lett. 196 (1-2): 109-12. PMID 7501234.
  • Hinuma S, Hosoya M, Ogi K, et al. (1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.". Biochim. Biophys. Acta 1219 (2): 251-9. PMID 7918619.
  • Morrison N, Duthie SM, Boyd E, et al. (1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.". Hum. Genet. 93 (6): 716-8. PMID 8005602.
  • Yamada M, Monden T, Konaka S, Mori M (1994). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.". Somat. Cell Mol. Genet. 19 (6): 577-80. PMID 8128317.
  • Duthie SM, Taylor PL, Anderson L, et al. (1994). "Cloning and functional characterisation of the human TRH receptor.". Mol. Cell. Endocrinol. 95 (1-2): R11-5. PMID 8243797.
  • Matre V, Karlsen HE, Wright MS, et al. (1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor.". Biochem. Biophys. Res. Commun. 195 (1): 179-85. doi:10.1006/bbrc.1993.2027. PMID 8395824.
  • Yamada M, Monden T, Satoh T, et al. (1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.". Biochem. Biophys. Res. Commun. 195 (2): 737-45. doi:10.1006/bbrc.1993.2107. PMID 8396925.
  • Iwasaki T, Yamada M, Satoh T, et al. (1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.". J. Biol. Chem. 271 (36): 22183-8. PMID 8703031.
  • Cook JV, McGregor A, Lee T, et al. (1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.". Endocrinology 137 (7): 2851-8. PMID 8770906.
  • Collu R, Tang J, Castagné J, et al. (1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 82 (5): 1561-5. PMID 9141550.
  • Petrou C, Tashjian AH (1999). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.". Cell. Signal. 10 (8): 553-9. PMID 9794253.
  • Matre V, Høvring PI, Orstavik S, et al. (1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.". J. Neurochem. 72 (1): 40-50. PMID 9886052.
  • Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.". J. Biol. Chem. 276 (16): 12736-43. doi:10.1074/jbc.M011311200. PMID 11278883.
  • Zhu CC, Cook LB, Hinkle PM (2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.". J. Biol. Chem. 277 (31): 28228-37. doi:10.1074/jbc.M204221200. PMID 12023974.
  • Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.". J. Biol. Chem. 277 (52): 50422-30. doi:10.1074/jbc.M209340200. PMID 12393857.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Cook LB, Zhu CC, Hinkle PM (2004). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.". Mol. Endocrinol. 17 (9): 1777-91. doi:10.1210/me.2003-0073. PMID 12805411.
  • Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.". Endocr. J. 50 (4): 459-67. PMID 14599121.
  • Cook LB, Hinkle PM (2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.". Endocrinology 145 (7): 3095-100. doi:10.1210/en.2004-0304. PMID 15117874.

External links

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin likeAcetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin likeBrain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromoneCalcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / SmoothenedFrizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened
v • d • e
Neuropeptide receptors
Hypothalamic hormone receptorsCRH - FSH - LHRH - TRH - Somatostatin
Pituitary hormone receptorsVasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH
Other hormone receptorsAtrial natriuretic factor - Calcitonin - Cholecystokinin (A, B) - VIP
Opioid receptorsDelta - Kappa - Mu - Sigma (1, 2) - Nociceptin
Other neuropeptide receptorsAngiotensin - Bradykinin (B1, B2) / Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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