Topotecan

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Topotecan
Systematic (IUPAC) name
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione monohydrochloride
Identifiers
CAS number	119413-54-6
ATC code	L01XX17
PubChem	6419854
DrugBank	APRD00687
Chemical data
Formula	C23H23N3O5 •HCl
Mol. mass	457.9 g/mol
Pharmacokinetic data
Bioavailability	NA
Protein binding	35%
Metabolism	Hepatic
Half life	2-3 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	D (Au, U.S.)
Legal status	℞-only (U.S.), POM (UK)
Routes	Intravenous infusion, oral

WikiDoc Resources for Topotecan
Articles
Most recent articles on Topotecan Most cited articles on Topotecan Review articles on Topotecan Articles on Topotecan in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Topotecan Images of Topotecan Photos of Topotecan Podcasts & MP3s on Topotecan Videos on Topotecan
Evidence Based Medicine
Cochrane Collaboration on Topotecan Bandolier on Topotecan TRIP on Topotecan
Clinical Trials
Ongoing Trials on Topotecan at Clinical Trials.gov Trial results on Topotecan Clinical Trials on Topotecan at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Topotecan NICE Guidance on Topotecan NHS PRODIGY Guidance FDA on Topotecan CDC on Topotecan
Books
Books on Topotecan
News
Topotecan in the news Be alerted to news on Topotecan News trends on Topotecan
Commentary
Blogs on Topotecan
Definitions
Definitions of Topotecan
Patient Resources / Community
Patient resources on Topotecan Discussion groups on Topotecan Patient Handouts on Topotecan Directions to Hospitals Treating Topotecan Risk calculators and risk factors for Topotecan
Healthcare Provider Resources
Symptoms of Topotecan Causes & Risk Factors for Topotecan Diagnostic studies for Topotecan Treatment of Topotecan
Continuing Medical Education (CME)
CME Programs on Topotecan
International
Topotecan en Espanol Topotecan en Francais
Businness
Topotecan in the Marketplace Patents on Topotecan
Experimental / Informatics
List of terms related to Topotecan

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Overview

Topotecan hydrochloride (Hycamtin) is a chemotherapy agent that is a topoisomerase 1 inhibitor. It is used to treat ovarian cancer and lung cancer, as well as other cancer types.

After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15, 2007, Topotecan is the first topoisomerase inhibitor for oral use.

Administration

IV, oral.

Side effects

• Diarrhea
• Low blood counts
• Susceptibility to infection

See also

NCI Drug Dictionary Definition of Topotecan
NCI Drug Information for Patients

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Topotecan
Articles on Topotecan	Most recent articles on Topotecan • Most cited articles on Topotecan • Review articles on Topotecan • Articles on Topotecan in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Topotecan	Powerpoint slides on Topotecan • Images of Topotecan • Photos of Topotecan • Podcasts & MP3s on Topotecan • Videos on Topotecan
Evidence Based Medicine Regarding Topotecan	Cochrane Collaboration on Topotecan • Bandolier on Topotecan • TRIP on Topotecan
Cost Effectiveness of Topotecan	Cost Effectiveness of Topotecan
Clinical Trials Involving Topotecan	Ongoing Trials on Topotecan at Clinical Trials.gov • Trial results on Topotecan • Clinical Trials on Topotecan at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Topotecan	US National Guidelines Clearinghouse on Topotecan • NICE Guidance on Topotecan • NHS PRODIGY Guidance • FDA on Topotecan • CDC on Topotecan
Textbook Information on Topotecan	Books and Textbook Information on Topotecan
Pharmacology Resources on Topotecan	Dosing of Topotecan • Drug interactions with Topotecan • Side effects of Topotecan • Allergic reactions to Topotecan • Overdose information on Topotecan • Carcinogenicity information on Topotecan • Topotecan in pregnancy • Pharmacokinetics of Topotecan •
Genetics, Pharmacogenomics, and Proteinomics of Topotecan	Genetics of Topotecan • Pharmacogenomics of Topotecan • Proteomics of Topotecan
Newstories on Topotecan	Topotecan in the news • Be alerted to news on Topotecan • News trends on Topotecan
Commentary on Topotecan	Blogs on Topotecan
Patient Resources on Topotecan	Patient resources on Topotecan • Discussion groups on Topotecan • Patient Handouts on Topotecan • Directions to Hospitals Treating Topotecan • Risk calculators and risk factors for Topotecan
Healthcare Provider Resources on Topotecan	Symptoms of Topotecan • Causes & Risk Factors for Topotecan • Diagnostic studies for Topotecan • Treatment of Topotecan
Continuing Medical Education (CME) Programs on Topotecan	CME Programs on Topotecan
International Resources on Topotecan	Topotecan en Espanol • Topotecan en Francais
Business Resources on Topotecan	Topotecan in the Marketplace • Patents on Topotecan
Informatics Resources on Topotecan	List of terms related to Topotecan

de:Topotecanfi:Topotekaani

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .