Total body irradiation
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Total Body Irradiation (TBI) is a radiotherapy technique used to ablate the bone marrow and immune system prior to bone marrow transplantation or peripheral blood stem cell transplantation. It may be used as part of high-dose treatment of some leukaemias and lymphomas. The aim of this type of ablative therapy is to prevent rejection of the transplanted cells.
During TBI the whole body is irradiated to between 9 to 14 Gy, a dose which, though modest by normal radiotherapy standards (when restricted to a small portion of the body, usually the tumor site) would be lethal when absorbed by the entire body if not directly followed by the transplant.
Organ transplantation | |
|---|---|
| Types | Allograft · Alloplant · Allotransplantation · Autotransplantation · Xenotransplantation |
| Organs and tissues | Bone · Bone marrow · Corneal · Face · Hand · Heart · Heart-lung · Kidney · Liver · Lung · Pancreas · Penis · Skin · Spleen · Uterus |
| Related topics | Biomedical tissue · Cellular memory · Edmonton protocol · Eye bank · Graft-versus-host disease · Immunosuppressive drugs · Islet cell transplantation · Implants · Living donor liver transplantation · Lung allocation score · Machine perfusion · Medical grafting · Non-heart beating donation · Organ donation · Post-transplant lymphoproliferative disorder · Repugnant market · Total body irradiation · Transplant rejection |
| Organizations | Halachic Organ Donor Society · Human Tissue Authority · National Marrow Donor Program · United Network for Organ Sharing |
| People | Christiaan Barnard · Michael Woodruff · Alexis Carrel · Norman Shumway · Jean-Michel Dubernard · List of notable organ transplant donors and recipients |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
