Transcortin

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
Identifiers
Symbol	SERPINA6
Alt. Symbols	CBG
Entrez	866
HUGO	1540
OMIM	122500
RefSeq	NM_001750
UniProt	P08185
Other data
Locus	Chr. 14 q32.1

WikiDoc Resources for Transcortin
Articles
Most recent articles on Transcortin Most cited articles on Transcortin Review articles on Transcortin Articles on Transcortin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Transcortin Images of Transcortin Photos of Transcortin Podcasts & MP3s on Transcortin Videos on Transcortin
Evidence Based Medicine
Cochrane Collaboration on Transcortin Bandolier on Transcortin TRIP on Transcortin
Clinical Trials
Ongoing Trials on Transcortin at Clinical Trials.gov Trial results on Transcortin Clinical Trials on Transcortin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Transcortin NICE Guidance on Transcortin NHS PRODIGY Guidance FDA on Transcortin CDC on Transcortin
Books
Books on Transcortin
News
Transcortin in the news Be alerted to news on Transcortin News trends on Transcortin
Commentary
Blogs on Transcortin
Definitions
Definitions of Transcortin
Patient Resources / Community
Patient resources on Transcortin Discussion groups on Transcortin Patient Handouts on Transcortin Directions to Hospitals Treating Transcortin Risk calculators and risk factors for Transcortin
Healthcare Provider Resources
Symptoms of Transcortin Causes & Risk Factors for Transcortin Diagnostic studies for Transcortin Treatment of Transcortin
Continuing Medical Education (CME)
CME Programs on Transcortin
International
Transcortin en Espanol Transcortin en Francais
Businness
Transcortin in the Marketplace Patents on Transcortin
Experimental / Informatics
List of terms related to Transcortin

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Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.

It is an alpha-globulin.

Binding

Transcortin binds several proteins:

• Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.

• Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.

• Progesterone

Production

Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.

See also

• Sex hormone binding globulin
• Serpin

External links

• MeSH Transcortin

v • d • e Proteins: carrier proteins
Hormone	Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
Metal/element	calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor)
Vitamin	Retinol binding protein (4) - Transcobalamin
Other	Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein

v • d • e Globulins: alpha globulins
Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - Alpha 2-antiplasmin - Antithrombin - Ceruloplasmin - Haptoglobin - Heparin cofactor II - Orosomucoid - Retinol binding protein - Transcortin

v • d • e Serpins
inhibitory	Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor
noninhibitory	Maspin - Ovalbumin - Heat shock protein 47 - Thyroxine-binding globulin - Transcortin

v • d • e Protein: glycoproteins

Activin - ADAM protein - Alpha 1-antichymotrypsin - Apolipoprotein H - CD70 - Asialoglycoprotein - Avidin - B-cell activating factor - 4-1BB ligand - Cholesterylester transfer protein - Clusterin - Colony-stimulating factor - Haemopexin - Inhibin - Lactoferrin - Membrane glycoproteins - Mucoprotein - Myelin protein zero - Osteonectin - Protein C - Protein S - Proteoglycan - Serum Amyloid P component - Sialoglycoprotein (CD43, Glycophorin, Glycophorin C) - Thrombopoietin - Thyroglobulin - Thyroxine-binding proteins - Transcortin - Tumor necrosis factor-alpha - Uteroglobin - Vitronectin

v • d • e WikiDoc Research Resources for Transcortin
Articles on Transcortin	Most recent articles on Transcortin • Most cited articles on Transcortin • Review articles on Transcortin • Articles on Transcortin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Transcortin	Powerpoint slides on Transcortin • Images of Transcortin • Photos of Transcortin • Podcasts & MP3s on Transcortin • Videos on Transcortin
Evidence Based Medicine Regarding Transcortin	Cochrane Collaboration on Transcortin • Bandolier on Transcortin • TRIP on Transcortin
Cost Effectiveness of Transcortin	Cost Effectiveness of Transcortin
Clinical Trials Involving Transcortin	Ongoing Trials on Transcortin at Clinical Trials.gov • Trial results on Transcortin • Clinical Trials on Transcortin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Transcortin	US National Guidelines Clearinghouse on Transcortin • NICE Guidance on Transcortin • NHS PRODIGY Guidance • FDA on Transcortin • CDC on Transcortin
Textbook Information on Transcortin	Books and Textbook Information on Transcortin
Pharmacology Resources on Transcortin	Dosing of Transcortin • Drug interactions with Transcortin • Side effects of Transcortin • Allergic reactions to Transcortin • Overdose information on Transcortin • Carcinogenicity information on Transcortin • Transcortin in pregnancy • Pharmacokinetics of Transcortin •
Genetics, Pharmacogenomics, and Proteinomics of Transcortin	Genetics of Transcortin • Pharmacogenomics of Transcortin • Proteomics of Transcortin
Newstories on Transcortin	Transcortin in the news • Be alerted to news on Transcortin • News trends on Transcortin
Commentary on Transcortin	Blogs on Transcortin
Patient Resources on Transcortin	Patient resources on Transcortin • Discussion groups on Transcortin • Patient Handouts on Transcortin • Directions to Hospitals Treating Transcortin • Risk calculators and risk factors for Transcortin
Healthcare Provider Resources on Transcortin	Symptoms of Transcortin • Causes & Risk Factors for Transcortin • Diagnostic studies for Transcortin • Treatment of Transcortin
Continuing Medical Education (CME) Programs on Transcortin	CME Programs on Transcortin
International Resources on Transcortin	Transcortin en Espanol • Transcortin en Francais
Business Resources on Transcortin	Transcortin in the Marketplace • Patents on Transcortin
Informatics Resources on Transcortin	List of terms related to Transcortin

de:Transcortin

fr:Transcortine

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .