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The tuberoinfundibular pathway refers to a population of dopamine neurons in the arcuate nucleus of the mediobasal hypothalamus (the 'tuberal region') that project to the median eminence (the 'infundibular region'). It is one of the four major dopamine pathways in the brain. Dopamine released at this site regulates the secretion of prolactin from the anterior pituitary gland.
Some antipsychotic drugs block dopamine in the tuberoinfundibular pathway, which can cause an increase in blood prolactin levels (hyperprolactinemia). This can cause abnormal lactation (even in men), disruptions to the menstrual cycle in women, visual problems, headache and sexual dysfunction.
Other major dopamine pathways include:
See also
External links
| Brain: telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) |
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| Frontal lobe | Precentral gyrus (Primary motor cortex, 4)
Superior frontal gyrus/Frontal eye fields (6, 8, 9), Middle frontal gyrus (46), Inferior frontal gyrus/Broca's area (44-Pars opercularis, 45-Pars triangularis)
Orbitofrontal cortex (10, 11, 12, 47)
Prefrontal cortex, Premotor cortex
Precentral sulcus - Superior frontal sulcus - Inferior frontal sulcus - Olfactory sulcus |
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| Parietal lobe | Somatosensory cortex (Primary (1, 2, 3, 43), Secondary (5)), Precuneus (7m) - Parietal operculum
Parietal lobules (Superior (7l), Inferior (40)), Angular gyrus (39)
Intraparietal sulcus, Marginal sulcus |
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| Occipital lobe | Primary visual cortex (17), (Cuneus, Lingual gyrus, Lateral occipital gyrus (18, 19))
Calcarine fissure |
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| Temporal lobe | Primary auditory cortex (41, 42), Superior temporal gyrus (38, 22/Wernicke's area), Middle temporal gyrus (21), Inferior temporal gyrus (20)
Fusiform gyrus (37) Medial temporal lobe (Amygdala, Parahippocampal gyrus (27, 28, 34, 35, 36) |
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| Cingulate cortex/gyrus | Subgenual area (25), Anterior cingulate (24, 32, 33), Posterior cingulate (23, 31), Retrosplenial cortex (26, 29, 30)
Callosal sulcus |
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| Interlobar sulci/fissures | lateral: Central (frontal+parietal), Lateral (frontal+parietal+temporal), Parietoöccipital
medial: Medial longitudinal, Cingulate (frontal+cingulate), Collateral (temporal+occipital) |
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| White matter tracts | Commissural fibers - Association fibers
Internal capsule (Anterior limb, Genu, Posterior limb), Corona radiata, External capsule, Lamina terminalis, Extreme capsule, Semioval center
Olfactory tract, Terminal stria |
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| Other | Insular cortex
gray: Olfactory bulb, Anterior olfactory nucleus, Basal optic nucleus of Meynert, Substantia innominata, Anterior perforated substance
Corpus striatum - Limbic lobe |
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| Some categorizations are approximations, and some Brodmann areas span gyri. |
