Tyrosine-tRNA ligase

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In enzymology, a tyrosine-tRNA ligase (EC 6.1.1.1) is an enzyme that catalyzes the chemical reaction

ATP + L-tyrosine + tRNATyr AMP + diphosphate + L-tyrosyl-tRNATyr

The 3 substrates of this enzyme are ATP, L-tyrosine, and tRNA(Tyr), whereas its 3 products are AMP, diphosphate, and L-tyrosyl-tRNA(Tyr).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tyrosine:tRNATyr ligase (AMP-forming). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 34 structures have been solved for this class of enzymes, with PDB accession codes 1H3E, 1J1U, 1JH3, 1JII, 1JIJ, 1JIK, 1JIL, 1N3L, 1NTG, 1Q11, 1TYA, 1TYB, 1TYC, 1TYD, 1U7D, 1U7X, 1VBM, 1VBN, 1WQ3, 1WQ4, 1X8X, 1Y42, 1ZH0, 1ZH6, 2AG6, 2CYA, 2CYB, 2CYC, 2DLC, 2HGZ, 2J5B, 2TS1, 3TS1, and 4TS1.

References

• IUBMB entry for 6.1.1.1
• BRENDA references for 6.1.1.1 (Recommended.)
• PubMed references for 6.1.1.1
• PubMed Central references for 6.1.1.1
• Google Scholar references for 6.1.1.1
• ALLEN EH, GLASSMAN E, SCHWEET RS (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes". J. Biol. Chem. 235: 1061–7. PMID 13792726.
• Cowles JR, Key JL (1972). "Demonstration of two tyrosyl-tRNA synthetases of pea roots". Biochim. Biophys. Acta. 281: 33–44. PMID 4563531.
• HOLLEY RW, BRUNNGRABER EF, SAAD F, WILLIAMS HH (1961). "Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of patassium ions on the activity of the tyrosine enzyme". J. Biol. Chem. 236: 197–9. PMID 13715350.
• Schweet RS and Allen EH (1958). "Purification and properties of tyrosine-activating enzyme of hog pancreas". J. Biol. Chem. 233: 1104–1108.
• Brick P, Bhat TN, Blow DM (1989). "Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution Interaction of the enzyme with the tyrosyl adenylate intermediate". J. Mol. Biol. 208: 83–98. PMID 2504923.

External links

The CAS registry number for this enzyme class is 9023-45-4.

• IUBMB entry for 6.1.1.1

• KEGG entry for 6.1.1.1

• BRENDA entry for 6.1.1.1

• NiceZyme view of 6.1.1.1

• EC2PDB: PDB structures for 6.1.1.1

• PRIAM entry for 6.1.1.1

• PUMA2 entry for 6.1.1.1

• IntEnz: Integrated Enzyme entry for 6.1.1.1

• MetaCyc entry for 6.1.1.1

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004831: tyrosine-tRNA ligase

• AMIGO entry for GO code 0004831: tyrosine-tRNA ligase

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