Ulcers

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

WikiDoc Resources for Ulcers
Articles
Most recent articles on Ulcers Most cited articles on Ulcers Review articles on Ulcers Articles on Ulcers in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Ulcers Images of Ulcers Photos of Ulcers Podcasts & MP3s on Ulcers Videos on Ulcers
Evidence Based Medicine
Cochrane Collaboration on Ulcers Bandolier on Ulcers TRIP on Ulcers
Clinical Trials
Ongoing Trials on Ulcers at Clinical Trials.gov Trial results on Ulcers Clinical Trials on Ulcers at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Ulcers NICE Guidance on Ulcers NHS PRODIGY Guidance FDA on Ulcers CDC on Ulcers
Books
Books on Ulcers
News
Ulcers in the news Be alerted to news on Ulcers News trends on Ulcers
Commentary
Blogs on Ulcers
Definitions
Definitions of Ulcers
Patient Resources / Community
Patient resources on Ulcers Discussion groups on Ulcers Patient Handouts on Ulcers Directions to Hospitals Treating Ulcers Risk calculators and risk factors for Ulcers
Healthcare Provider Resources
Symptoms of Ulcers Causes & Risk Factors for Ulcers Diagnostic studies for Ulcers Treatment of Ulcers
Continuing Medical Education (CME)
CME Programs on Ulcers
International
Ulcers en Espanol Ulcers en Francais
Businness
Ulcers in the Marketplace Patents on Ulcers
Experimental / Informatics
List of terms related to Ulcers

• Most ulcers are caused by an infection, not spicy food, acid or stress.

• The most common ulcer symptom is burning pain in the stomach.

• Your doctor can test you for H. pylori infection.

• Antibiotics are the new cure for ulcers.

• Eliminating H. pylori infections with antibiotics means that your ulcer can be cured for good.

Also known as:

Peptic Ulcer Disease

References

http://www.cdc.gov/ulcer/

Epidemiology and Demographics

Approximately two-thirds of the world's population is infected with H. pylori. In the United States, H. pylori is more prevalent among older adults, African Americans, Hispanics, and lower socioeconomic groups.

Approximately 25 million Americans suffer from peptic ulcer disease at some point in their lifetime. Each year there are 500,000 to 850,000 new cases of peptic ulcer disease and more than one million ulcer-related hospitalizations.

References

http://www.cdc.gov/ulcer/keytocure.htm

http://www.cdc.gov/ulcer/keytocure.htm

Risk Factors

References

Screening

References

Pathophysiology & Etiology

Helicobacter pylori (H. pylori) is a spiral-shaped bacterium that is found in the gastric mucous layer or adherent to the epithelial lining of the stomach. H. pylori causes more than 90% of duodenal ulcers and up to 80% of gastric ulcers. Before 1982, when this bacterium was discovered, spicy food, acid, stress, and lifestyle were considered the major causes of ulcers. The majority of patients were given long-term medications, such as H2 blockers, and more recently, proton pump inhibitors, without a chance for permanent cure. These medications relieve ulcer-related symptoms, heal gastric mucosal inflammation, and may heal the ulcer, but they do NOT treat the infection. When acid suppression is removed, the majority of ulcers, particularly those caused by H. pylori, recur. Since we now know that most ulcers are caused by H. pylori, appropriate antibiotic regimens can successfully eradicate the infection in most patients, with complete resolution of mucosal inflammation and a minimal chance for recurrence of ulcers.

References

http://www.cdc.gov/ulcer/keytocure.htm

Molecular Biology

References

Genetics

References

Natural History

References

Diagnosis

Differential Diagnosis

References

History and Symptoms

The most common ulcer symptom is gnawing or burning pain in the epigastrium. This pain typically occurs when the stomach is empty, between meals and in the early morning hours, but it can also occur at other times. It may last from minutes to hours and may be relieved by eating or by taking antacids. Less common ulcer symptoms include nausea, vomiting, and loss of appetite. Bleeding can also occur; prolonged bleeding may cause anemia leading to weakness and fatigue. If bleeding is heavy, hematemesis, hematochezia, or melena may occur.

References

http://www.cdc.gov/ulcer/keytocure.htm

Physical Examination

Appearance of the Patient

Vital Signs

Skin

Eyes

Ear Nose and Throat

Heart

Lungs

Abdomen

Extremities

Neurologic

Other

References

Laboratory Findings

Electrolyte and Biomarker Studies

References

Electrocardiogram

References

Chest X Ray

References

MRI and CT

References

Echocardiography or Ultrasound

References

Other Imaging Findings

References

Other Diagnostic Studies

References

Risk Stratification and Prognosis

References

Treatment

Pharmacotherapy

Acute Pharmacotherapies

References

Chronic Pharmacotherapies

References

Surgery and Device Based Therapy

Indications for Surgery

References

Pre-Operative Assessment

References

Post-Operative Management

References

Transplantation

References

Primary Prevention

References

Secondary Prevention

References

Cost-Effectiveness of Therapy

References

Future or Investigational Therapies

References

"The Way I Like To Do It ..." Tips and Tricks From Clinicians Around The World

Suggested Revisions to the Current Guidelines

References

<biblio>

</biblio>

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

List of contributors:

Suggested Reading and Key General References

Suggested Links and Web Resources

For Patients

---

v • d • e WikiDoc Research Resources for Ulcers (Click show to right to view)
Articles on Ulcers	Most recent articles on Ulcers • Most cited articles on Ulcers • Review articles on Ulcers • Articles on Ulcers in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Ulcers	Powerpoint slides on Ulcers • Images of Ulcers • Photos of Ulcers • Podcasts & MP3s on Ulcers • Videos on Ulcers
Evidence Based Medicine Regarding Ulcers	Cochrane Collaboration on Ulcers • Bandolier on Ulcers • TRIP on Ulcers
Cost Effectiveness of Ulcers	Cost Effectiveness of Ulcers
Clinical Trials Involving Ulcers	Ongoing Trials on Ulcers at Clinical Trials.gov • Trial results on Ulcers • Clinical Trials on Ulcers at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Ulcers	US National Guidelines Clearinghouse on Ulcers • NICE Guidance on Ulcers • NHS PRODIGY Guidance • FDA on Ulcers • CDC on Ulcers
Textbook Information on Ulcers	Books and Textbook Information on Ulcers
Pharmacology Resources on Ulcers	Dosing of Ulcers • Drug interactions with Ulcers • Side effects of Ulcers • Allergic reactions to Ulcers • Overdose information on Ulcers • Carcinogenicity information on Ulcers • Ulcers in pregnancy • Pharmacokinetics of Ulcers •
Genetics, Pharmacogenomics, and Proteinomics of Ulcers	Genetics of Ulcers • Pharmacogenomics of Ulcers • Proteomics of Ulcers
Newstories on Ulcers	Ulcers in the news • Be alerted to news on Ulcers • News trends on Ulcers
Commentary on Ulcers	Blogs on Ulcers
Patient Resources on Ulcers	Patient resources on Ulcers • Discussion groups on Ulcers • Patient Handouts on Ulcers • Directions to Hospitals Treating Ulcers • Risk calculators and risk factors for Ulcers
Healthcare Provider Resources on Ulcers	Symptoms of Ulcers • Causes & Risk Factors for Ulcers • Diagnostic studies for Ulcers • Treatment of Ulcers
Continuing Medical Education (CME) Programs on Ulcers	CME Programs on Ulcers
International Resources on Ulcers	Ulcers en Espanol • Ulcers en Francais
Business Resources on Ulcers	Ulcers in the Marketplace • Patents on Ulcers
Informatics Resources on Ulcers	List of terms related to Ulcers

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .