Uracil mustard

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Image:Uramustine.svg
Uracil mustard
Systematic (IUPAC) name
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Identifiers
CAS number	66-75-1
ATC code	?
PubChem	6194
DrugBank	APRD00130
Chemical data
Formula	C8H11Cl2N3O2
Mol. mass	252.097 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	5%
Metabolism	?
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

WikiDoc Resources for Uracil mustard
Articles
Most recent articles on Uracil mustard Most cited articles on Uracil mustard Review articles on Uracil mustard Articles on Uracil mustard in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Uracil mustard Images of Uracil mustard Photos of Uracil mustard Podcasts & MP3s on Uracil mustard Videos on Uracil mustard
Evidence Based Medicine
Cochrane Collaboration on Uracil mustard Bandolier on Uracil mustard TRIP on Uracil mustard
Clinical Trials
Ongoing Trials on Uracil mustard at Clinical Trials.gov Trial results on Uracil mustard Clinical Trials on Uracil mustard at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Uracil mustard NICE Guidance on Uracil mustard NHS PRODIGY Guidance FDA on Uracil mustard CDC on Uracil mustard
Books
Books on Uracil mustard
News
Uracil mustard in the news Be alerted to news on Uracil mustard News trends on Uracil mustard
Commentary
Blogs on Uracil mustard
Definitions
Definitions of Uracil mustard
Patient Resources / Community
Patient resources on Uracil mustard Discussion groups on Uracil mustard Patient Handouts on Uracil mustard Directions to Hospitals Treating Uracil mustard Risk calculators and risk factors for Uracil mustard
Healthcare Provider Resources
Symptoms of Uracil mustard Causes & Risk Factors for Uracil mustard Diagnostic studies for Uracil mustard Treatment of Uracil mustard
Continuing Medical Education (CME)
CME Programs on Uracil mustard
International
Uracil mustard en Espanol Uracil mustard en Francais
Businness
Uracil mustard in the Marketplace Patents on Uracil mustard
Experimental / Informatics
List of terms related to Uracil mustard

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Overview

Uracil mustard or uramustine is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Uracil mustard
Articles on Uracil mustard	Most recent articles on Uracil mustard • Most cited articles on Uracil mustard • Review articles on Uracil mustard • Articles on Uracil mustard in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Uracil mustard	Powerpoint slides on Uracil mustard • Images of Uracil mustard • Photos of Uracil mustard • Podcasts & MP3s on Uracil mustard • Videos on Uracil mustard
Evidence Based Medicine Regarding Uracil mustard	Cochrane Collaboration on Uracil mustard • Bandolier on Uracil mustard • TRIP on Uracil mustard
Cost Effectiveness of Uracil mustard	Cost Effectiveness of Uracil mustard
Clinical Trials Involving Uracil mustard	Ongoing Trials on Uracil mustard at Clinical Trials.gov • Trial results on Uracil mustard • Clinical Trials on Uracil mustard at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Uracil mustard	US National Guidelines Clearinghouse on Uracil mustard • NICE Guidance on Uracil mustard • NHS PRODIGY Guidance • FDA on Uracil mustard • CDC on Uracil mustard
Textbook Information on Uracil mustard	Books and Textbook Information on Uracil mustard
Pharmacology Resources on Uracil mustard	Dosing of Uracil mustard • Drug interactions with Uracil mustard • Side effects of Uracil mustard • Allergic reactions to Uracil mustard • Overdose information on Uracil mustard • Carcinogenicity information on Uracil mustard • Uracil mustard in pregnancy • Pharmacokinetics of Uracil mustard •
Genetics, Pharmacogenomics, and Proteinomics of Uracil mustard	Genetics of Uracil mustard • Pharmacogenomics of Uracil mustard • Proteomics of Uracil mustard
Newstories on Uracil mustard	Uracil mustard in the news • Be alerted to news on Uracil mustard • News trends on Uracil mustard
Commentary on Uracil mustard	Blogs on Uracil mustard
Patient Resources on Uracil mustard	Patient resources on Uracil mustard • Discussion groups on Uracil mustard • Patient Handouts on Uracil mustard • Directions to Hospitals Treating Uracil mustard • Risk calculators and risk factors for Uracil mustard
Healthcare Provider Resources on Uracil mustard	Symptoms of Uracil mustard • Causes & Risk Factors for Uracil mustard • Diagnostic studies for Uracil mustard • Treatment of Uracil mustard
Continuing Medical Education (CME) Programs on Uracil mustard	CME Programs on Uracil mustard
International Resources on Uracil mustard	Uracil mustard en Espanol • Uracil mustard en Francais
Business Resources on Uracil mustard	Uracil mustard in the Marketplace • Patents on Uracil mustard
Informatics Resources on Uracil mustard	List of terms related to Uracil mustard

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .