Urushiol

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For information on urushiol poisoning, see Urushiol-induced contact dermatitis.

Urushiol (IPA pronunciation: [ʊˈɹuʃiˌɔl]) is an oil found in plants of the Family Anacardiaceae, especially Toxicodendron spp. (e.g. poison oak, poison ivy, and poison sumac). It is also found in the nut shell of cashew fruit (Anacardium occidentale) and on the skin of the mango fruit. It causes an allergic skin rash on contact, known as urushiol-induced contact dermatitis. The name comes from the Japanese word urushi, which denotes a lacquer produced in East Asia from the sap of kiurushi trees (Lacquer Tree). The oxidation and polymerization of urushiol in the tree's sap in the presence of moisture allows it to form a hard lacquer, which is used to produce traditional Chinese and Japanese lacquerwares.

Urushiol is a yellow liquid with a boiling point of 200-210 °C. It is miscible partially in alcohol and ether, but nearly immiscible in water. Chemically, urushiol is a mixture of several closely related organic compounds. Each consists of a catechol substituted with an alkyl chain that has 15 or 17 carbon atoms. The alkyl group may be saturated or unsaturated, urushiol oil is a mixture of the saturated and unsaturated urushiol molecules. The exact mixture depends on the species of the plant. For example, poison oak urushiol contains mostly catechols with C₁₇ side chains, but poison ivy and poison sumac contain mostly catechols with C₁₅ side chains. The allergic reaction is dependent on the degree of unsaturation of the alkyl chain. Less than half of the general population reacts with the saturated urushiol alone, but over 90% react with urushiol containing at least two degrees of unsaturation (double bonds).

Image:Urushiol.svg

R = (CH2)14CH3 or R = (CH2)7CH=CH(CH2)5CH3 or R = (CH2)7CH=CHCH2CH=CH(CH2)2CH3 or R = (CH2)7CH=CHCH2CH=CHCH=CHCH3 or R = (CH2)7CH=CHCH2CH=CHCH2CH=CH2 and others

See also

• Burow's solution, for treating the toxin
• Bentoquatam, a barrier creme
• Hapten
• Mangoes, the skin
• Poison ivy
• Toxin
• Western Poison-oak
• Pistachio
• Cashew
• Anti-itch drug

External links

• Poison Oak at Wayne's Word
• The Poison Ivy Tutorialde:Urushiol

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .