VPg
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VPg is a protein attached to the 5' end of RNA during RNA synthesis in a wide variety of viruses including Poliovirus and Picornavirus. VPg stands for "viral protein genome-linked".
Attachment during RNA synthesis
3CDpro (a protease) cleaves VPg from membrane-bound 3AB. 3Dpol (polivirus' RNA polymerase) then synthesizes VPg-pUpU using the sequence AAACA from the cre (cis-acting replication element) of the template strand. The 3Dpol-VPg-pUpU complex then moves to the 3' poly(A) tail of the template strand and commences RNA synthesis using the pUpU sequence as a primer.
Sources
Principles of Virology by S.J. Flint, L.W. Enquist, V.R. Racaniello, A.M. Skalka (ISBN 1-55581-259-7)
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
