Virchow's node
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| Lymph: Virchow's node | ||
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| Regional lymph tissue. (Supraclavicular near top, in green.)⋅ | ||
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| Deep Lymph Nodes 1. Submental 2. Submandibular (Submaxillary) Anterior Cervical Lymph Nodes (Deep) 3. Prelaryngeal 4. Thyroid 5. Pretracheal 6. Paratracheal Deep Cervical Lymph Nodes 7. Lateral jugular 8. Anterior jugular 9. Jugulodigastric Inferior Deep Cervical Lymph Nodes 10. Juguloomohyoid 11. Supraclavicular (scalene) | ||
| Gray's | subject #177 697 | |
| Dorlands/Elsevier | n_09/12575322 | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
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Overview
Virchow's node (or signal node) is an enlarged, hard, left supraclavicular lymph node which can contain metastasis of visceral (abdominal) malignancy.
Clinical significance
Malignancies of the internal organs can reach an advanced stage before giving symptoms. Stomach cancer, for example, can remain symptomless while metastatizing. One of the first visible spots where these tumors metastatise is the left supraclavicular lymph node. The left supraclavicular node is the classical Virchow's node because it is on the left side of the neck where the lymphatic drainage of most of the body (from the thoracic duct) enters the venous circulation via the left subclavian vein.
Differential diagnosis of an enlarged Virchow's node includes lymphoma, various intra-abdominal malignancies, breast cancer, lung cancer, and infection (e.g. of the arm).
Eponym
It is named after Rudolf Virchow (1821-1902), the German pathologist who first described the association. The presence of an enlarged Virchow's node is also referred to as Troisier's sign, named after Charles Emile Troisier, who also described this.
Because an enlarged Virchow's node is often a harbinger of malignant disease, it is sometimes called the sentinel node. This needs to be contrasted with the technique of sentinel lymph node biopsy. It should also not be confused with the 'sentinel gland' of the greater omentum.[1]
Additional images
 Superficial lymph glands and lymphatic vessels of head and neck. |
References
External links
- synd/1222 at Who Named It
- 1973026851 at GPnotebook
- HEM39 at FPnotebook
- Mizutani M, Nawata S, Hirai I, Murakami G, Kimura W (2005). "Anatomy and histology of Virchow's node.". Anat Sci Int 80 (4): 193-8. PMID 16333915.
Acknowledgements
The content on this page was first contributed by: C. Michael Gibson M.S., M.D.
Symptoms and signs (R00-R69, 780-789) |
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| Circulatory and respiratory systems |
Tachycardia - Bradycardia - Palpitation - Heart murmur - Nosebleed - Hemoptysis - Cough - abnormalities of breathing (Dyspnea, Orthopnoea, Stridor, Wheeze, Cheyne-Stokes respiration, Hyperventilation, Mouth breathing, Hiccup, Bradypnea, Hypoventilation) - Chest pain - Asphyxia - Pleurisy - Respiratory arrest - Sputum - Bruit |
| Digestive system and abdomen | Abdominal pain - Acute abdomen - Nausea - Vomiting - Heartburn - Dysphagia - Flatulence - Burping - Fecal incontinence - Encopresis - Hepatomegaly - Splenomegaly - Hepatosplenomegaly - Jaundice - Ascites - Fecal occult blood - Halitosis |
| Skin and subcutaneous tissue | disturbances of skin sensation (Hypoesthesia, Paresthesia, Hyperesthesia) - Rash - Cyanosis - Pallor - Flushing - Petechia - Desquamation - Induration |
| Nervous and musculoskeletal systems |
abnormal involuntary movements (Tremor, Spasm, Fasciculation, Athetosis) - Gait abnormality - lack of coordination (Ataxia, Dysmetria, Dysdiadochokinesia, Hypotonia) - Tetany - Meningism - Hyperreflexia |
| Urinary system | Dysuria - Vesical tenesmus - Urinary incontinence - Urinary retention - Oliguria - Polyuria - Nocturia |
| Cognition, perception, emotional state and behaviour |
Anxiety - Somnolence - Coma - Amnesia (Anterograde amnesia, Retrograde amnesia) - Dizziness/Vertigo - smell and taste (Anosmia, Ageusia, Parosmia, Parageusia) |
| Speech and voice | speech disturbances (Dysphasia, Aphasia, Dysarthria) - symbolic dysfunctions (Dyslexia, Alexia, Agnosia, Apraxia, Acalculia, Agraphia) - voice disturbances (Dysphonia, Aphonia) |
| General symptoms and signs | Fever (Hyperpyrexia) - Headache - Chronic pain - Malaise - Fatigue - Fainting (Vasovagal syncope) - Febrile seizure - Shock (Cardiogenic shock) - Lymphadenopathy - Edema (Peripheral edema, Anasarca) - Hyperhidrosis (Sleep hyperhidrosis) - Delayed milestone - Failure to thrive - food and fluid intake (Anorexia, Polydipsia, Polyphagia) - Cachexia - Xerostomia - Clubbing |
WikiDoc Research Resources for Virchow's node | |
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| Articles on Virchow's node | Most recent articles on Virchow's node • Most cited articles on Virchow's node • Review articles on Virchow's node • Articles on Virchow's node in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Virchow's node | Powerpoint slides on Virchow's node • Images of Virchow's node • Photos of Virchow's node • Podcasts & MP3s on Virchow's node • Videos on Virchow's node |
| Evidence Based Medicine Regarding Virchow's node | Cochrane Collaboration on Virchow's node • Bandolier on Virchow's node • TRIP on Virchow's node |
| Cost Effectiveness of Virchow's node | Cost Effectiveness of Virchow's node |
| Clinical Trials Involving Virchow's node | Ongoing Trials on Virchow's node at Clinical Trials.gov • Trial results on Virchow's node • Clinical Trials on Virchow's node at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Virchow's node | US National Guidelines Clearinghouse on Virchow's node • NICE Guidance on Virchow's node • NHS PRODIGY Guidance • FDA on Virchow's node • CDC on Virchow's node |
| Textbook Information on Virchow's node | Books and Textbook Information on Virchow's node |
| Pharmacology Resources on Virchow's node | Dosing of Virchow's node • Drug interactions with Virchow's node • Side effects of Virchow's node • Allergic reactions to Virchow's node • Overdose information on Virchow's node • Carcinogenicity information on Virchow's node • Virchow's node in pregnancy • Pharmacokinetics of Virchow's node • |
| Genetics, Pharmacogenomics, and Proteinomics of Virchow's node | Genetics of Virchow's node • Pharmacogenomics of Virchow's node • Proteomics of Virchow's node |
| Newstories on Virchow's node | Virchow's node in the news • Be alerted to news on Virchow's node • News trends on Virchow's node |
| Commentary on Virchow's node | Blogs on Virchow's node |
| Patient Resources on Virchow's node | Patient resources on Virchow's node • Discussion groups on Virchow's node • Patient Handouts on Virchow's node • Directions to Hospitals Treating Virchow's node • Risk calculators and risk factors for Virchow's node |
| Healthcare Provider Resources on Virchow's node | Symptoms of Virchow's node • Causes & Risk Factors for Virchow's node • Diagnostic studies for Virchow's node • Treatment of Virchow's node |
| Continuing Medical Education (CME) Programs on Virchow's node | CME Programs on Virchow's node |
| International Resources on Virchow's node | Virchow's node en Espanol • Virchow's node en Francais |
| Business Resources on Virchow's node | Virchow's node in the Marketplace • Patents on Virchow's node |
| Informatics Resources on Virchow's node | List of terms related to Virchow's node |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
