Wassermann test

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The Wassermann test is a complement-fixation (Complement system) antibody test for syphilis, named after the bacteriologist August von Wassermann.

Method

A sample of blood or cerebrospinal fluid is taken and introduced to the antigen - cardiolipin extracted from bovine muscle or heart. Syphilis-specific antibodies (reagines) react with the lipid - the Wassermann reaction of antiphospholipid antibodies (APAs). The intensity of the reaction (1, 2, 3, or 4) indicates the severity of the condition.

Uncertainty

The reaction is not actually specific to syphilis and will produce a positive reaction to other diseases, including malaria, tuberculosis, and numerous other diseases. It is possible for an infected individual to produce no reaction and for a successfully treated individual to continue to produce a reaction (called Wassermann fast or fixed).

Development and refinement

The antibody test was developed by Wassermann and Albert Neisser at the Robert Koch Institute for Infectious Diseases in 1906.^[1][1] The test was a growth from the work of Jules Jean Baptiste Vincent Bordet and Octave Gengou on complementing-fixation reaction, published in 1901, and the positive reaction is sometimes called the Bordet-Gengou-Wassermann reaction or Bordet-Wassermann reaction.

The Wassermann test has been refined - Kahn test, Kolmer test - and it is rarely used today. Replacement tests (VDRL test, Rapid plasma reagent (RPR test), initially based on flocculation techniques (Hinton), have been shown to produce far fewer false positive results. Indeed the "biologic false positives" of modern tests usually indicate a serious alternate condition, often an autoimmune disease.

References

External links

• MeSH Wassermann+reaction

v • d • e WikiDoc Research Resources for Wassermann test
Articles on Wassermann test	Most recent articles on Wassermann test • Most cited articles on Wassermann test • Review articles on Wassermann test • Articles on Wassermann test in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Wassermann test	Powerpoint slides on Wassermann test • Images of Wassermann test • Photos of Wassermann test • Podcasts & MP3s on Wassermann test • Videos on Wassermann test
Evidence Based Medicine Regarding Wassermann test	Cochrane Collaboration on Wassermann test • Bandolier on Wassermann test • TRIP on Wassermann test
Cost Effectiveness of Wassermann test	Cost Effectiveness of Wassermann test
Clinical Trials Involving Wassermann test	Ongoing Trials on Wassermann test at Clinical Trials.gov • Trial results on Wassermann test • Clinical Trials on Wassermann test at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Wassermann test	US National Guidelines Clearinghouse on Wassermann test • NICE Guidance on Wassermann test • NHS PRODIGY Guidance • FDA on Wassermann test • CDC on Wassermann test
Textbook Information on Wassermann test	Books and Textbook Information on Wassermann test
Pharmacology Resources on Wassermann test	Dosing of Wassermann test • Drug interactions with Wassermann test • Side effects of Wassermann test • Allergic reactions to Wassermann test • Overdose information on Wassermann test • Carcinogenicity information on Wassermann test • Wassermann test in pregnancy • Pharmacokinetics of Wassermann test •
Genetics, Pharmacogenomics, and Proteinomics of Wassermann test	Genetics of Wassermann test • Pharmacogenomics of Wassermann test • Proteomics of Wassermann test
Newstories on Wassermann test	Wassermann test in the news • Be alerted to news on Wassermann test • News trends on Wassermann test
Commentary on Wassermann test	Blogs on Wassermann test
Patient Resources on Wassermann test	Patient resources on Wassermann test • Discussion groups on Wassermann test • Patient Handouts on Wassermann test • Directions to Hospitals Treating Wassermann test • Risk calculators and risk factors for Wassermann test
Healthcare Provider Resources on Wassermann test	Symptoms of Wassermann test • Causes & Risk Factors for Wassermann test • Diagnostic studies for Wassermann test • Treatment of Wassermann test
Continuing Medical Education (CME) Programs on Wassermann test	CME Programs on Wassermann test
International Resources on Wassermann test	Wassermann test en Espanol • Wassermann test en Francais
Business Resources on Wassermann test	Wassermann test in the Marketplace • Patents on Wassermann test
Informatics Resources on Wassermann test	List of terms related to Wassermann test

nl:Wassermannreactie

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .