Whipple disease

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Overview

WikiDoc Resources for Whipple disease
Articles
Most recent articles on Whipple disease Most cited articles on Whipple disease Review articles on Whipple disease Articles on Whipple disease in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Whipple disease Images of Whipple disease Photos of Whipple disease Podcasts & MP3s on Whipple disease Videos on Whipple disease
Evidence Based Medicine
Cochrane Collaboration on Whipple disease Bandolier on Whipple disease TRIP on Whipple disease
Clinical Trials
Ongoing Trials on Whipple disease at Clinical Trials.gov Trial results on Whipple disease Clinical Trials on Whipple disease at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Whipple disease NICE Guidance on Whipple disease NHS PRODIGY Guidance FDA on Whipple disease CDC on Whipple disease
Books
Books on Whipple disease
News
Whipple disease in the news Be alerted to news on Whipple disease News trends on Whipple disease
Commentary
Blogs on Whipple disease
Definitions
Definitions of Whipple disease
Patient Resources / Community
Patient resources on Whipple disease Discussion groups on Whipple disease Patient Handouts on Whipple disease Directions to Hospitals Treating Whipple disease Risk calculators and risk factors for Whipple disease
Healthcare Provider Resources
Symptoms of Whipple disease Causes & Risk Factors for Whipple disease Diagnostic studies for Whipple disease Treatment of Whipple disease
Continuing Medical Education (CME)
CME Programs on Whipple disease
International
Whipple disease en Espanol Whipple disease en Francais
Businness
Whipple disease in the Marketplace Patents on Whipple disease
Experimental / Informatics
List of terms related to Whipple disease

Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei.^[1] First described by George Hoyt Whipple in 1907^[1][1] and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, lungs, brain, joints, and eyes. Weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system are common presenting symptoms.^[1] When recognized and treated, Whipple's disease can usually be cured; untreated the disease may be fatal.

Symptoms

• arthritis
• malabsorption
• intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine)
• lymphadenopathy
• abdominal pain
• diarrhea
• fever
• neurological symptoms
  • cognitive changes
  • nystagmus

Diagnosis

Symptoms of Whipple's disease include joint problems, reduced vision, and intestinal inflammation (including diarrhea). Diagnosis is made by intestinal biopsy, which shows as PAS-positive macrophage inclusions.

At times, small bowel X-rays may show some thickened folds.

Treatment

Treatment is with penicillin, ampicillin, tetracycline or co-trimoxazole for 1 -2 years.^[1] Any treatment lasting less than a year has an approximate relapse rate of 40%. In the January 4, 2007 issue of the New England Journal of Medicine, Fenollar et al suggest the use of doxycycline with hydroxychloroquine for 12 to 18 months. Sulfonamides (Sulfadiazine or Sulfamethoxazole) should be added for treatment of neurological symptoms.^[1]

References

External links

• NIH
• Merck

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Initial content for this page in some instances came from Wikipedia

List of contributors:

Suggested Reading and Key General References

Suggested Links and Web Resources

For Patients

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v • d • e WikiDoc Research Resources for Whipple disease
Articles on Whipple disease	Most recent articles on Whipple disease • Most cited articles on Whipple disease • Review articles on Whipple disease • Articles on Whipple disease in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Whipple disease	Powerpoint slides on Whipple disease • Images of Whipple disease • Photos of Whipple disease • Podcasts & MP3s on Whipple disease • Videos on Whipple disease
Evidence Based Medicine Regarding Whipple disease	Cochrane Collaboration on Whipple disease • Bandolier on Whipple disease • TRIP on Whipple disease
Cost Effectiveness of Whipple disease	Cost Effectiveness of Whipple disease
Clinical Trials Involving Whipple disease	Ongoing Trials on Whipple disease at Clinical Trials.gov • Trial results on Whipple disease • Clinical Trials on Whipple disease at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Whipple disease	US National Guidelines Clearinghouse on Whipple disease • NICE Guidance on Whipple disease • NHS PRODIGY Guidance • FDA on Whipple disease • CDC on Whipple disease
Textbook Information on Whipple disease	Books and Textbook Information on Whipple disease
Pharmacology Resources on Whipple disease	Dosing of Whipple disease • Drug interactions with Whipple disease • Side effects of Whipple disease • Allergic reactions to Whipple disease • Overdose information on Whipple disease • Carcinogenicity information on Whipple disease • Whipple disease in pregnancy • Pharmacokinetics of Whipple disease •
Genetics, Pharmacogenomics, and Proteinomics of Whipple disease	Genetics of Whipple disease • Pharmacogenomics of Whipple disease • Proteomics of Whipple disease
Newstories on Whipple disease	Whipple disease in the news • Be alerted to news on Whipple disease • News trends on Whipple disease
Commentary on Whipple disease	Blogs on Whipple disease
Patient Resources on Whipple disease	Patient resources on Whipple disease • Discussion groups on Whipple disease • Patient Handouts on Whipple disease • Directions to Hospitals Treating Whipple disease • Risk calculators and risk factors for Whipple disease
Healthcare Provider Resources on Whipple disease	Symptoms of Whipple disease • Causes & Risk Factors for Whipple disease • Diagnostic studies for Whipple disease • Treatment of Whipple disease
Continuing Medical Education (CME) Programs on Whipple disease	CME Programs on Whipple disease
International Resources on Whipple disease	Whipple disease en Espanol • Whipple disease en Francais
Business Resources on Whipple disease	Whipple disease in the Marketplace • Patents on Whipple disease
Informatics Resources on Whipple disease	List of terms related to Whipple disease

it:Morbo di Whipple de:Morbus Whipplefr:Maladie de Whipple

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .