White sponge nevus
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Overview
| White sponge nevus Classification and external resources | |
| ICD-10 | GroupMajor.minor |
|---|---|
| ICD-9 | xxx |
| OMIM | 193900 |
| DiseasesDB | 33866 |
White sponge nevus, also known as a Cannon's disease or Hereditary leukokeratosis of mucosa, appears to follow a hereditary pattern as an autosomal dominant trait, with no sex preference. Although it is congeital in most cases, it can occur in childhood or adolescence.
It is caused by a mutation of the keratin 4 and keratin 13 genes.
It presents in the mouth, most frequently as a thick bilateral white plaque with a spongy texture, usually on the buccal mucosa, but sometimes on the labial mucosa, alveolar ridge or floor of the mouth. the gingival margin and dorsum of the tongue are almost never affected.
Although this condition is perfectly benign, it is often mistaken for leukoplakia. There is no treatment, but because there are no serious clinical complications, the prognosis is excellent.
References
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
