XX male syndrome

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XX male syndrome (also called de la Chapelle syndrome) is a rare sex chromosomal disorder in men. Usually it is caused by unequal crossing over between X and Y chromosomes during meiosis. Symptoms include small testes, gynecomastia and sterility.

Men typically have one X chromosome and one Y chromosome in each diploid cell of their bodies. Women typically have two X chromosomes. XX males have two X chromosomes, but otherwise appear to be male.

In fiction

• The main character of the Japanese manga The Day of Revolution, Kei Yoshikawa, may have XX male syndrome. The author doesn't identify his exact condition.

See also

• X chromosome, for other diseases related to the X chromosome.

References

• de la Chapelle A (1972). "Analytic review: nature and origin of males with XX sex chromosomes". Am J Hum Genet 24 (1): 71-105. PMID 4622299.

External links

• Online 'Mendelian Inheritance in Man' (OMIM) 278850

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .