Zadik Barak Levin syndrome

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Zadik Barak Levin Syndrome (ZBLS) is a congenital disorder in humans. Presenting conditions include primary hypothyroidism, cleft palate, hypodontia, and ectodermal dysplasia. It is the result of an embryonic defect in the mesodermal-ectodermal midline development.

Frequent signs

• anodontia/oligodontia — no teeth or fewer teeth than normal
• cleft palate
• depressed nasal bridge
• dry skin
• ectopic/agenesis/hypoplastic thyroid
• epibulbar dermoid
• frontal bossing
• hypertelorism
• hypothyroidy
• lordosis
• macroglossia
• microcephaly
• micrognatia/retrognatia — small or recessed jaw(s)
• polyhydramnios
• short stature/dwarfism
• sparse/absent scalp hair(generalized)
• squint/paresis of ocular muscles
• umbilical hernia

References

• Zadik, Z. and Y. Barak, S. Levin, Z. Josephberg, J. Lustmann, J. Chemke. "Dermoid cysts, hyperthyroidism, cleft palate, and hypodontia," J. Clin. Dysmorphol., 1983 Winter, 1(4):24-7.
• Zadik Barak Levin syndrome, About rare diseases, Orphanet.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .