Zona pellucida
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| Zona pellucida | |
|---|---|
 | |
| Human ovum. The zona pellucida is seen as a thick clear girdle surrounded by the cells of the corona radiata. | |
| Gray's | subject #3 38 |
| MeSH | Zona+Pellucida |
| Dorlands/Elsevier | z_01/12869767 |
The zona pellucida (or zona striata in older texts) is a glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it.
This structure binds spermatozoa, and is required to initiate the acrosome reaction.
The zona glycoprotein, ZP3, is responsible for sperm binding, adhering to proteins on the sperm plasma membrane. There is evidence that ZP3 is then involved in the induction of the acrosome reaction, whereby a spermatozoon releases the contents of the acrosomal vesicle.
Function in humans
In humans, five days after the fertilization, the blastocyst performs zona hatching; the zona pellucida degenerates and decomposes to be replaced by the underlying layer of trophoblastic cells.
The zona pellucida is essential for oocyte survival and fertilization.
Immunocontraception
Glycoproteins in ZP1, 2, and 3 are targets for immunocontraception.
In non-mammalian animals, the zona pellucida (called vitelline layer) plays an important role in preventing breeding of different species, especially in species that fertilize outside of the body (e.g. fish).
The zona pellucida is commonly used to control wildlife population problems by immunocontraception. When the zona pellucida of one animal species is injected into the bloodstream of another, it results in sterility of the second species due to immune response. This effect can be temporary or permanent, depending on the method used. In New Jersey, Porcine zona pellucida is used to keep deer populations low, and this process is commonly referred to as "spay-vac".
Additional images
Follicle histology.gif
Early folliculogenesis from primordial to early tertiary. |
 First stages of segmentation of a mammalian ovum. |
 Section of vesicular ovarian follicle of cat. x50. |
References
- Oehninger S (2003). "Biochemical and functional characterization of the human zona pellucida.". Reprod Biomed Online 7 (6): 641-8. PMID 14748962.
- Bagnell, C. 2005. "Animal Reproduction". Rutgers University Department of Animal Sciences.
External links
- Histology at BU 18404loa - "Female Reproductive System: ovary, cumulus oophorus "
- Histology at BU 14805loa - "Female Reproductive System: ovary, multilaminar primary follicle"
- Histology at USC rep/c_7
- Histology at USC rep/c_12
- Organology at UC Davis Reproductive/mammal/ovary2/ovary7 - "Mammal, canine ovary (LM, High)"
- Image at um.edu.mt
- Image at um.edu.mt
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
