Zymogen

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Overview

A zymogen (or proenzyme) is an inactive enzyme precursor. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in a lysosome where a specific part of the precursor enzyme is cleaved in order to activate it. The amino acid chain that is released upon activation is called the activation peptide.

Etymology

Very often the suffix "-ogen" can be added to the name of the enzyme to indicate that it is in the precursor form. Some enzymes have a pro- prefix to denote their inactive status e.g. Proalbumin, which is converted into albumin. [2]

Examples

Examples of zymogens:

• Trypsinogen
• Chymotrypsinogen
• Pepsinogen
• Most proteins in the coagulation system
• Some of the proteins of the complement system
• Caspases
• Proelastase
• Prolipase

See also

• Webster entry on zymogen
• Wiktionary entry on zyme/zymogencs:Zymogen

da:Zymogen de:Zymogen he:זימוגן

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .