Difference between revisions of "Middle East respiratory syndrome coronavirus infection pathophysiology"

Jump to: navigation, search
Line 8: Line 8:
 
==Pathophysiology==
 
==Pathophysiology==
 
===The Microorganism===
 
===The Microorganism===
[[MERS|Middle East Respiratory Syndrome]] ([[MERS]]) is a [[viral]] [[respiratory disease|respiratory illness]] caused by an emerging [[coronavirus]], [[MERS|Middle East Respiratory Syndrome coronavirus]] (MERS-CoV) that was previously known as human betaCoV 2c EMC/2012 (hCoV-EMC).<ref name="pmid23078800">{{cite journal| author=Bermingham A, Chand MA, Brown CS, Aarons E, Tong C, Langrish C et al.| title=Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. | journal=Euro Surveill | year= 2012 | volume= 17 | issue= 40 | pages= 20290 | pmid=23078800 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23078800  }} </ref><ref name="pmid23075143">{{cite journal| author=Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA| title=Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. | journal=N Engl J Med | year= 2012 | volume= 367 | issue= 19 | pages= 1814-20 | pmid=23075143 | doi=10.1056/NEJMoa1211721 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23075143  }} </ref><ref name="pmid23678167">{{cite journal| author=de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L et al.| title=Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. | journal=J Virol | year= 2013 | volume= 87 | issue= 14 | pages= 7790-2 | pmid=23678167 | doi=10.1128/JVI.01244-13 | pmc=PMC3700179 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23678167  }} </ref>  MERS-CoV belongs to the genera betacoronavirus of the family   coronaviridae, the largest of all the RNA viruses, with positive single-stranded RNA genomes of 26–32 kb.<ref name="pmid23770275">{{cite journal| author=Chan JF, To KK, Tse H, Jin DY, Yuen KY| title=Interspecies transmission and emergence of novel viruses: lessons from bats and birds. | journal=Trends Microbiol | year= 2013 | volume= 21 | issue= 10 | pages= 544-55 | pmid=23770275 | doi=10.1016/j.tim.2013.05.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23770275  }} </ref>
+
[[MERS|Middle East Respiratory Syndrome]] ([[MERS]]) is a [[viral]] [[respiratory disease|respiratory illness]] caused by an emerging [[coronavirus]], [[MERS|Middle East Respiratory Syndrome coronavirus]] (MERS-CoV) that was previously known as human betaCoV 2c EMC/2012 (hCoV-EMC).<ref name="pmid23078800">{{cite journal| author=Bermingham A, Chand MA, Brown CS, Aarons E, Tong C, Langrish C et al.| title=Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. | journal=Euro Surveill | year= 2012 | volume= 17 | issue= 40 | pages= 20290 | pmid=23078800 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23078800  }} </ref><ref name="pmid23075143">{{cite journal| author=Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA| title=Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. | journal=N Engl J Med | year= 2012 | volume= 367 | issue= 19 | pages= 1814-20 | pmid=23075143 | doi=10.1056/NEJMoa1211721 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23075143  }} </ref><ref name="pmid23678167">{{cite journal| author=de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L et al.| title=Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. | journal=J Virol | year= 2013 | volume= 87 | issue= 14 | pages= 7790-2 | pmid=23678167 | doi=10.1128/JVI.01244-13 | pmc=PMC3700179 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23678167  }} </ref>  MERS-CoV belongs to the genera betacoronavirus of the family coronaviridae, the largest of all the RNA viruses, with positive single-stranded RNA genomes of 26–32 kb.<ref name="pmid23770275">{{cite journal| author=Chan JF, To KK, Tse H, Jin DY, Yuen KY| title=Interspecies transmission and emergence of novel viruses: lessons from bats and birds. | journal=Trends Microbiol | year= 2013 | volume= 21 | issue= 10 | pages= 544-55 | pmid=23770275 | doi=10.1016/j.tim.2013.05.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23770275  }} </ref> It shares several similarities with SARS-CoV, another betacoronavirus.
  
 
===Encounter With the Microorganism===
 
===Encounter With the Microorganism===

Revision as of 19:53, 20 June 2014

Middle East Respiratory Syndrome Coronavirus Infection Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Middle East Respiratory Syndrome Coronavirus Infection from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

Other Diagnostic Studies

Treatment

Medical Therapy

Contact and Airborne Precautions

Primary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Middle East respiratory syndrome coronavirus infection pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Middle East respiratory syndrome coronavirus infection pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Middle East respiratory syndrome coronavirus infection pathophysiology

CDC on Middle East respiratory syndrome coronavirus infection pathophysiology

Middle East respiratory syndrome coronavirus infection pathophysiology in the news

Blogs on Middle East respiratory syndrome coronavirus infection pathophysiology

Directions to Hospitals Treating Middle East respiratory syndrome coronavirus infection

Risk calculators and risk factors for Middle East respiratory syndrome coronavirus infection pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. It is caused by an emerging coronavirus, specifically a betacoronavirus called MERS-CoV (Middle East Respiratory Syndrome Coronavirus), first discovered in 2012. Potential animal reservoirs and mechanisms of transmission of MERS-CoV to humans remain unclear. Initially a zoonotic origin for MERS-CoV was suggested due to the high genetic similarity to the coronaviruses in bats. Additionally, recent reports have also described serologic data similarities in camels and related viruses have also been identified in bats. However, future studies will have to provide additional epidemiologic data linking human MERS cases to infected animals in order to determine if a particular species is a host, a source of human infection, or both.[1][2]

Pathophysiology

The Microorganism

Middle East Respiratory Syndrome (MERS) is a viral respiratory illness caused by an emerging coronavirus, Middle East Respiratory Syndrome coronavirus (MERS-CoV) that was previously known as human betaCoV 2c EMC/2012 (hCoV-EMC).[3][4][5] MERS-CoV belongs to the genera betacoronavirus of the family coronaviridae, the largest of all the RNA viruses, with positive single-stranded RNA genomes of 26–32 kb.[6] It shares several similarities with SARS-CoV, another betacoronavirus.

Encounter With the Microorganism

Colonization

Penetration of Antimicrobial Barrier

Spread

Mechanism of Damage

Resolution

References

  1. "Clinical management of severe acute respiratory infections when novel coronavirus is suspected: What to do and what not to do" (PDF).
  2. "MERS Prevention and Treatment".
  3. Bermingham A, Chand MA, Brown CS, Aarons E, Tong C, Langrish C; et al. (2012). "Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012". Euro Surveill. 17 (40): 20290. PMID 23078800.
  4. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA (2012). "Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia". N Engl J Med. 367 (19): 1814–20. doi:10.1056/NEJMoa1211721. PMID 23075143.
  5. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L; et al. (2013). "Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group". J Virol. 87 (14): 7790–2. doi:10.1128/JVI.01244-13. PMC 3700179. PMID 23678167.
  6. Chan JF, To KK, Tse H, Jin DY, Yuen KY (2013). "Interspecies transmission and emergence of novel viruses: lessons from bats and birds". Trends Microbiol. 21 (10): 544–55. doi:10.1016/j.tim.2013.05.005. PMID 23770275.

Linked-in.jpg