Anaphylaxis primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD


Prevention is very important in anaphylaxis to protect patients against repeated episodes. Patients should see an allergist to identify their allergens so they can avoid being triggered by them. [1]

Primary Prevention

Prevention of anaphylaxis is by the patient becoming aware of their triggers and avoiding it. It is also important to manage comorbid conditions such as asthma, cardiovascular disease, and mastocytosis which increase the severity of anaphylaxis. Patients should be aware that taking beta blockers can block the response to administration of epinephrine. Compliance among patience to carry an epinephrine auto injection should be encouraged. [2] In the case of children, food is the most common culprit. Therefore, mothers should be careful in introducing new foods to their children. [3] In case of an active episode, patients and healthcare providers should prioritize removing the patient from the potential allergen immediately. Once the episode has resolved patients should be referred to an allergist to identify possible causes to avoid them in the future. [4] [5]


  1. LoVerde D, Iweala OI, Eginli A, Krishnaswamy G (2018). "Anaphylaxis". Chest. 153 (2): 528–543. doi:10.1016/j.chest.2017.07.033. PMC 6026262. PMID 28800865.
  2. Irani AM, Akl EG (2015). "Management and Prevention of Anaphylaxis". F1000Res. 4. doi:10.12688/f1000research.7181.1. PMC 4754021. PMID 26918144.
  3. Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID Check |pmid= value (help).
  4. Simons FE (2010). "Anaphylaxis". J Allergy Clin Immunol. 125 (2 Suppl 2): S161–81. doi:10.1016/j.jaci.2009.12.981. PMID 20176258.
  5. Simons FE, Ardusso LR, Bilò MB, El-Gamal YM, Ledford DK, Ring J; et al. (2011). "World Allergy Organization anaphylaxis guidelines: summary". J Allergy Clin Immunol. 127 (3): 587-93.e1-22. doi:10.1016/j.jaci.2011.01.038. PMID 21377030.

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