Back pain pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]


Back pain can be broadly classified into inflammatory, mechanical, degenerative, oncologic and infectious. Lumbar disc disease have been linked to genetic involvment. The risk of developing lumbar disc disease increases if found in other close relatives. Genes involved in the pathogenesis of back pain include, HLA-B27, SOX5, CCDC26/GSDMC, and DCC.


Type of back pain Pathophysiology
Inflammatory Inflammation of joints (sacroiliitis), inflammation of enthesis (spondyloarthritis)
Mechanical Trauma, muscle sprain, extra weight on muscles (pregnancy, heavy lifting),
Oncologic Lytic lesions in spine, nerve compression due to mass effect, pathologic fracture due to weakened bone
Degenerative Cartilage degradation and bone remodeling decreases elasticity and causes pain , fractures can also occur due to osteoporosis,
Infectious Infection involving spine, disc, joints, abscess formation.


Associated Conditions


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