Jump to navigation Jump to search
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass645.67 g/mol
3D model (JSmol)

WikiDoc Resources for Cefoperazone


Most recent articles on Cefoperazone

Most cited articles on Cefoperazone

Review articles on Cefoperazone

Articles on Cefoperazone in N Eng J Med, Lancet, BMJ


Powerpoint slides on Cefoperazone

Images of Cefoperazone

Photos of Cefoperazone

Podcasts & MP3s on Cefoperazone

Videos on Cefoperazone

Evidence Based Medicine

Cochrane Collaboration on Cefoperazone

Bandolier on Cefoperazone

TRIP on Cefoperazone

Clinical Trials

Ongoing Trials on Cefoperazone at Clinical Trials.gov

Trial results on Cefoperazone

Clinical Trials on Cefoperazone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Cefoperazone

NICE Guidance on Cefoperazone


FDA on Cefoperazone

CDC on Cefoperazone


Books on Cefoperazone


Cefoperazone in the news

Be alerted to news on Cefoperazone

News trends on Cefoperazone


Blogs on Cefoperazone


Definitions of Cefoperazone

Patient Resources / Community

Patient resources on Cefoperazone

Discussion groups on Cefoperazone

Patient Handouts on Cefoperazone

Directions to Hospitals Treating Cefoperazone

Risk calculators and risk factors for Cefoperazone

Healthcare Provider Resources

Symptoms of Cefoperazone

Causes & Risk Factors for Cefoperazone

Diagnostic studies for Cefoperazone

Treatment of Cefoperazone

Continuing Medical Education (CME)

CME Programs on Cefoperazone


Cefoperazone en Espanol

Cefoperazone en Francais


Cefoperazone in the Marketplace

Patents on Cefoperazone

Experimental / Informatics

List of terms related to Cefoperazone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid, and also marked by Pharco B International under the name Cefazone and also marketed by Sigmatec Pharmaceuticals under the name Cefoperazone. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics. Cefina-SB is a combination of sulbactam and cefoperazone. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms. In some countries, the combination is sold as Sulperazone. Gepach International markets this combination of cefoperazone with sulbactam under the brand name Bacperazone.In India and SriLanka (Cefoperazone-Sulbactam) is manufacterd by Pfizer under the brand name of Magnex/Magnex-Forte depending on the Cefoperazone-Sulbactam ratio.

Spectrum of bacterial susceptibility

Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Haemophilus influenzae: 0.12 - 0.25 µg/ml
  • Staphylococcus aureus: 0.125 - 32 µg/ml
  • Streptococcus pneumoniae: ≤0.007 - 1 µg/ml[1][2]

Adverse effects

Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.[3]


  1. http://antibiotics.toku-e.com/antimicrobial_462_1.html
  2. http://www.toku-e.com/Assets/MIC/Cefoperazone%20sodium.pdf
  3. Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.