Dermatitis herpetiformis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Dermatitis Herpetiformis (also called Duhring's disease), is a chronic itchy rash which is frequently associated with Celiac Disease. The rash is made of papules and vesicles which are present on different parts of the body mostly commonly on neck, trunk, buttocks and knees. It is an autoimmune mediated skin condition, which is IgA mediated reaction and is associated with gluten sensitivity of small bowel. There is presence of antibodies which leads to positive serology test results.

Dermatitis herpetiformis is associated with high prevalence of other autoimmune diseases.


Dermatitis herpetiformis is an autoimmune skin manifestation of celiac disease. Approximately 10% patients suffering from celiac disease are affected by this rash, while more than 90% patients with the dermatitis herpetiformis eruptions are found to have gluten sensitive enteropathy which resembles to celiac disease. It is found that both genetic and environmental factors are the cause of development of the rash[1].


  1. Pekka Collin, Teea T. Salmi, Kaisa Hervonen, Katri Kaukinen & Timo Reunala (2017) Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease, Annals of Medicine, 49:1, 23-31, DOI: 10.1080/07853890.2016.1222450

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