Efferent arteriole

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The efferent arterioles are blood vessels that are part of the urinary system of many animals. The efferent arterioles form from a convergence of the capillaries of the glomerulus. They play an important role in maintaining the glomerular filtration rate despite fluctuations in blood pressure.

In the mammalian kidney they follow two markedly different courses, depending on the location of the glomeruli from which they arise.

In the mammalian kidney about 15% of glomeruli lie close to the boundary between the renal cortex and renal medulla and are known as juxtamedullary glomeruli. The rest are simply undifferentiated cortical glomeruli.

In undifferentiated cortical glomeruli

The efferent arterioles of the undifferentiated cortical glomeruli are the simplest.

Promptly on leaving the glomerulus they break up into capillaries and become part of a rich plexus of vessels surrounding the cortical portions of the renal tubules.

Their chief function is to receive the resorbate from these tubules and return it to the general circulation.

In juxtamedullary glomeruli

The efferent arterioles of the juxtamedullary glomeruli are much different. They do break up, but they form bundles of vessels (arteriolae recti) that cross the outer zone of the medulla to perfuse the inner zone.

Vessels returning from the inner medulla (venulae recti) intersperse themselves in a highly regular fashion among the descending arteriolae recti to form a well organized rete mirabile.

This rete is responsible for the osmotic isolation of the inner medulla from the rest of the kidney and so permits the excretion of a hypertonic urine when circumstances require.

Interestingly, since the rete also isolates the inner medulla from gaseous exchange, any metabolism in this area is anaerobic, and red cells, which would serve no purpose there, are ordinarily shunted from the arteriolae recti by an unknown mechanism into the capillary plexus surrounding the tubules of the outer zone of the medulla.

Blood in this plexus and returning from the inner medulla finds its way to the renal vein and the general circulation by pathways similar to those providing drainage for the rest of the cortex.

Regulation of glomerular filtration rate

When angiotensin levels are increased due to activation of the renin-angiotensin-aldosterone system, most of the arteries in the body experience vasoconstriction, in order to maintain adequate blood pressure. However, this reduces blood flow to the kidneys. To compensate, the efferent arterioles constrict to a greater degree than the other arteries, in response to increased levels of angiontensin. Pressure in glomerular capillaries is therefore maintained and glomerular filtration rate remains adequate.

See also

Afferent arteriole

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External links

  • Essentials of Human Physiology by Thomas M. Nosek. Section 7/7ch03/7ch03p10.
  • Template:UCDavisOrganology - "Mammal, renal vasculature (EM, Low)"
  • Histology at University of Southern California ren/c_11


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