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Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
End-systolic volume (ESV) is the volume of blood in the ventricles just after systole. The amount of blood in the ventricle at the end of the cardiac ejection period and immediately preceding the beginning of ventricular relaxation; a measurement of the adequacy of cardiac emptying, related to systolic function. On an ECG the End-systolic volume will be seen at the end of the T wave. It will be the lowest volume seen throughout the ECG.