Pre-eclampsia medical therapy

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Pre-eclampsia Microchapters


Patient Information


Historical Perspective




Differentiating Pre-eclampsia from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Directions to Hospitals Treating Pre-eclampsia

Risk calculators and risk factors for Pre-eclampsia medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Ogheneochuko Ajari, MB.BS, MS [3]



Medical Therapy

Serum Magnesium Concentration (mg/dL) Effect
5–9 Therapeutic range
>9 Loss of patellar reflexes
> 12 Respiratory paralysis
> 30 Cardiac arrest
Drugs for urgent controlling of hypertension in preeclampsia[3] Dose Specific considration Onset of action
Labetalol 10–20 mg IV, then 20–80 mg every 10–30 minutes upto a maximum dosage of 300 mg; or infusion 1–2 mg/min IV Contraindications: 1-2 minutes
Hydralazine 5 mg IV or IM, then 5–10 mg IV every 20–40 minutes upto a maximum dosage of 20 mg or keeping infusion of 0.5–10 mg/hr Side effects in higher dosage: 10-20 minutes
Nifedipine 10–20 mg orally, repeat in 20 minutes if needed; then 10–20 mg every 2–6 hours, maximum daily dose is 180 mg Side effect: 5-10 minutes


  1. . doi:10.1161/HYP.0000000000000065Hypertension. Check |doi= value (help). Missing or empty |title= (help)
  2. "Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222". Obstet Gynecol. 135 (6): e237–e260. June 2020. doi:10.1097/AOG.0000000000003891. PMID 32443079 Check |pmid= value (help).
  3. "Gestational Hypertension and Preeclampsia". Obstetrics & Gynecology. 135 (6): e237–e260. 2020. doi:10.1097/AOG.0000000000003891. ISSN 0029-7844.