Rhinosinusitis cost-effectiveness of therapy

Jump to navigation Jump to search

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]


Cost effectiveness of medical therapy and surgery is determined depending on the patients severity of disease. The cost effectiveness of biologic therapies needs more comprehensive research and is yet to be investigated.

Cost-effectiveness of Therapy

Medical therapy vs. Surgery

Current literature suggests that in patients with refractory chronic rhinosinusitis endoscopic sinus surgery(ESS) is superior to continued medical therapy in terms of symptom relief, quality of life and cost effectiveness with reported incremental cost effectiveness ratio (ICER) of five to thirteen thousand dollars per quality adjusted life year (QALY). Medical therapy mostly helps maintain the quality of life and health-state utility of the patients.[1][2][3][4]

Biologic therapies

Biologic therapies such as mepolizumab, omalizumab and dupilumab are recently introduced as alternative therapies for sever cases of chronic rhinosinusitis. To date, there has been insufficient evidence in the literature regarding their health care, social and economic cost effectiveness. It is suggested that use of biologic agents could prevent recurrence of the disease, and subsequently decrease the direct and indirect costs of the surgery. On the other hand the their high cost and need for multiple visits to the health care provider, should be considered. Thus, it is not easy to determine the cost-effectiveness of biologic agents in treatment of chronic rhinosinusitis and further prospective research with longer follow-up period is required.[2][5]


  1. Patel ZM, Thamboo A, Rudmik L, Nayak JV, Smith TL, Hwang PH (2017). "Surgical therapy vs continued medical therapy for medically refractory chronic rhinosinusitis: a systematic review and meta-analysis". Int Forum Allergy Rhinol. 7 (2): 119–127. doi:10.1002/alr.21872. PMID 27863163.
  2. 2.0 2.1 Codispoti CD, Mahdavinia M (2019). "A call for cost-effectiveness analysis for biologic therapies in chronic rhinosinusitis with nasal polyps". Ann Allergy Asthma Immunol. 123 (3): 232–239. doi:10.1016/j.anai.2019.07.004. PMID 31295554.
  3. Rudmik L, Soler ZM, Mace JC, Schlosser RJ, Smith TL (2015). "Economic evaluation of endoscopic sinus surgery versus continued medical therapy for refractory chronic rhinosinusitis". Laryngoscope. 125 (1): 25–32. doi:10.1002/lary.24916. PMC 4280303. PMID 25186499.
  4. Scangas GA, Su BM, Remenschneider AK, Shrime MG, Metson R (2016). "Cost utility analysis of endoscopic sinus surgery for chronic rhinosinusitis". Int Forum Allergy Rhinol. 6 (6): 582–9. doi:10.1002/alr.21697. PMID 26991813.
  5. Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D; et al. (2013). "Consolidated Health Economic Evaluation Reporting Standards (CHEERS)--explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force". Value Health. 16 (2): 231–50. doi:10.1016/j.jval.2013.02.002. PMID 23538175.

Template:WH Template:WS