Scleroderma laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]
Overview
Specific laboratory findings consistent with the diagnosis of scleroderma include: Anti-Scl-70 antibody (Topoisomerase I), anti-centromere antibody (CREST syndrome), anti-nuclear antibody (ANA), anti-RNA polymerase III antibody, anti-U1-RNP antibody.
Laboratory Findings
Laboratory findings consistent with the diagnosis of scleroderma include:[1]
- Anti-Scl-70 antibody (Topoisomerase I)
- Anti-centromere antibody (CREST syndrome)[2]
- Anti-nuclear antibody (ANA)
- Anti-RNA polymerase III antibody
- Anti-U1-RNP antibody
References
- ↑ Tan EM, Rodnan GP, Garcia I, Moroi Y, Fritzler MJ, Peebles C (June 1980). "Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome". Arthritis Rheum. 23 (6): 617–25. PMID 6155920.
- ↑ Powell FC, Winkelmann RK, Venencie-Lemarchand F, Spurbeck JL, Schroeter AL (October 1984). "The anticentromere antibody: disease specificity and clinical significance". Mayo Clin. Proc. 59 (10): 700–6. PMID 6384675.