Testicular cancer history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Testicular cancer Microchapters


Patient Information


Historical Perspective




Differentiating Testicular cancer from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis



History and Symptoms

Physical Examination

Laboratory Findings

X Ray




Other Imaging Findings

Other Diagnostic Studies



Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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The most common symptoms of testicular cancer include a painless lump in the testicle, swelling of the testicle, and weight loss.

History and Symptoms

Common Symptoms

Common symptoms of testicular cancer include:[1][2]

Less Common Symptoms

Leydig cell tumors

Sertoli cell tumors


  1. Motzer, Robert J.; Agarwal, Neeraj; Beard, Clair; Bhayani, Sam; Bolger, Graeme B.; Buyyounouski, Mark K.; Carducci, Michael A.; Chang, Sam S.; Choueiri, Toni K.; Gupta, Shilpa; Hancock, Steven L.; Hudes, Gary R.; Jonasch, Eric; Kuzel, Timothy M.; Lau, Clayton; Levine, Ellis G.; Lin, Daniel W.; Margolin, Kim A.; Michaelson, M. Dror; Olencki, Thomas; Pili, Roberto; Ratliff, Thomas W.; Redman, Bruce G.; Robertson, Cary N.; Ryan, Charles J.; Sheinfeld, Joel; Wang, Jue; Wilder, Richard B. (2012). "Testicular Cancer". Journal of the National Comprehensive Cancer Network. 10 (4): 502–535. doi:10.6004/jnccn.2012.0050. ISSN 1540-1405.
  2. Bosl GJ, Motzer RJ (July 1997). "Testicular germ-cell cancer". N. Engl. J. Med. 337 (4): 242–53. doi:10.1056/NEJM199707243370406. PMID 9227931.
  3. Tazi MF, Mellas S, El Fassi MJ, Farih MH (2008). "Leydig cell hyperplasia revealed by gynecomastia". Rev Urol. 10 (2): 164–7. PMC 2483322. PMID 18660859.
  4. Dilworth JP, Farrow GM, Oesterling JE (1991). "Non-germ cell tumors of testis". Urology. 37 (5): 399–417. PMID 2024387.
  5. Gabrilove JL, Freiberg EK, Leiter E, Nicolis GL (1980). "Feminizing and non-feminizing Sertoli cell tumors". J Urol. 124 (6): 757–67. doi:10.1016/s0022-5347(17)55652-9. PMID 7003168.

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