Ventricular remodeling historical perspective

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Ventricular Remodeling



Historical Perspective




Differentiating Ventricular Remodeling From Other Conditions

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor-in-Chief: Mohammad I. Barouqa, M.D. [2]

Historical Perspective

Historical terms such as Athelete's Heart, Soldier's Heart, Runner's Heart, and Effort Syndrome referring to cardiac adaptations that occur with prolonged endurance or excessive exertions were initially coined in the 19th century.[1][2] Sir William Osler described hypertrophy as a compensatory response during the development of the failing heart that precedes the state of broken compensation secondary to degeneration and weakening of the heart muscle.[3]

In the 1960s,animal models were investigated for the effects of pressure overload.Such investigations led Meerson to argue that cardiac growth induced by biomechanical stress has a protective role,at least in the short term.In the 1970s and 1980s, patients of valvular heart disease were investigated and their hemodynamic measurements showed that there is an adaptive hypertrophic growth taking place in the heart.Such growth can lead to systolic dysfunction when it is inadequate.[4]


  1. Berryman, Jack W.; Park, Roberta J. (1992). Sport and exercise science : essays in the history of sports medicin. Urbana: University of Illinois Press. ISBN 0-252-06242-6.
  2. Thompson, PD. (2004). "D. Bruce Dill Historical lecture. Historical concepts of the athlete's heart". Med Sci Sports Exerc. 36 (3): 363–70. PMID 15076776. Unknown parameter |month= ignored (help)
  3. "The principles and practice of medicine : designed for the use of practitioners and students of medicine : Osler, William, Sir, 1849-1919 : Free Download & Streaming : Internet Archive".
  4. Hill, JA.; Olson, EN. (2008). "Cardiac plasticity". N Engl J Med. 358 (13): 1370–80. doi:10.1056/NEJMra072139. PMID 18367740. Unknown parameter |month= ignored (help)